Table 1.
Baseline characteristics and change after bariatric surgery in biometric, DXA, and urinary menstrual cycle function parameters
| 1 month before surgery (baseline) Mean (sd) | 1-month postsurgery change from baseline |
3-month postsurgery change from baseline |
6-month postsurgery change from baseline |
12-month postsurgery change from baseline |
24-month postsurgery change from baseline |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Estimate (95% CI) | P value | Estimate (95% CI) | P value | Estimate (95% CI) | P value | Estimate (95% CI) | P value | Estimate (95% CI) | P value | ||
| Biometric parameters | |||||||||||
| Weight (kg) | 132 (17) | −15 (−17, −14) | <0.001 | −29 (−31, −27) | <0.001 | −40 (−43, −37) | <0.001 | −50 (−54, −45) | <0.001 | −51 (−59, −44) | <0.001 |
| BMI (kg/m2) | 49 (7) | −6 (−6, −5) | <0.001 | −11 (−11, −10) | <0.001 | −15 (−16, −13) | <0.001 | −18 (−20, −17) | <0.001 | −19 (−22, −16) | <0.001 |
| Waist (cm) | 129 (16) | −8 (−12, −3) | <0.001 | −23 (−28, −17) | <0.001 | −30 (−37, −23) | <0.001 | −37 (−46, −28) | <0.001 | −41 (−53, −29) | <0.001 |
| Ferriman-Gallwey score | 15 (8) | 0.4 (−0.2, 0.9) | 0.20 | 0.6 (−0.1, 1.4) | 0.10 | 0.6 (−0.5, 1.6) | 0.28 | 0.1 (−1.4, 1.5) | 0.92 | 0.0 (−2.5, 2.5) | 0.99 |
| Total acne count (comodones+papules+pustules) | 12 (15) | 3.3 (−0.2, 6.8) | 0.06 | 2.7 (−1.8, 7.1) | 0.24 | 1.1 (−4.4, 6.7) | 0.69 | −1.6 (−8.8, 5.5) | 0.65 | −2.6 (−12.5, 7.3) | 0.60 |
| Total sebumeter reading (left+center+right) | 239 (128) | −38 (−100, 24) | 0.22 | −61 (−135, 13) | 0.10 | −77 (−161, 8) | 0.07 | −63 (−163, 38) | 0.22 | −79 (−199, 41) | 0.19 |
| DXA parameters | |||||||||||
| Total bone mineral density (g/cm2) | 1.19 (0.08) | 0.01 (0.00, 0.02) | 0.22 | 0.01 (−0.01, 0.02) | 0.38 | 0.00 (−0.02, 0.02) | 0.68 | 0.00 (−0.03, 0.02) | 0.87 | −0.03 (−0.07, 0.01) | 0.20 |
| Bone mineral content (g) | 2500 (315) | 32 (4, 59) | 0.02 | 16 (−19, 51) | 0.36 | −24 (−68, 20) | 0.29 | −61 (−123, 1) | 0.05 | −127 (−225, −29) | 0.01 |
| Lean (kg) | 57 (5) | −5 (−7, −4) | <0.001 | −8 (−9, −6) | <0.001 | −9 (−11, −7) | <0.001 | −11 (−14, −8) | <0.001 | −13 (−16, −9) | <0.001 |
| Fat (kg) | 60 (8) | −7 (−9, −6) | <0.001 | −17 (−19, −14) | <0.001 | −26 (−29, −23) | <0.001 | −33 (−37, −29) | <0.001 | −34 (−39, −28) | <0.001 |
| Android fat (kg) | 6 (1) | −1 (−1, 0) | <0.001 | −2 (−2, −1) | <0.001 | −3 (−3, −2) | <0.001 | −4 (−4, −3) | <0.001 | −4 (−4, −3) | <0.001 |
| Gynoid fat (kg) | 8 (2) | −1 (−1, −1) | <0.001 | −2 (−3, −1) | <0.001 | −3 (−4, −3) | <0.001 | −4 (−5, −3) | <0.001 | −4 (−5, −3) | <0.001 |
| Urinary menstrual cycle function parameters | |||||||||||
| Menstrual cycle length (d) | 37.2 (24.6) | −2.5 (−9.4, 4.3) | 0.47 | −2.9 (−8.9, 3.1) | 0.34 | −6.0 (−11.7, −0.3) | 0.04 | −4.4 (−10.3, 1.4) | 0.14 | −4.1 (−10.6, 2.4) | 0.21 |
| Follicular phase length (d) | 22.0 (12.5) | −3.2 (−8.4, 2.1) | 0.23 | −6.5 (−10.5, −2.4) | 0.002 | −8.2 (−12.3, −4.2) | <0.001 | −7.9 (−12.1, −3.7) | <0.001 | −8.9 (−13.9, −3.9) | <0.001 |
| Luteal phase length (d) | 12.2 (2.4) | 3.8 (0.4, 7.2) | 0.03 | 0.0 (−2.6, 2.6) | 0.99 | 0.8 (−1.9, 3.4) | 0.57 | 0.8 (−2.0, 3.7) | 0.56 | 0.0 (−3.4, 3.4) | 1.00 |
| 28-d E13G AUC (ng/mg creatinine) | 565 (338) | −86 (−202, 31) | 0.15 | −22 (−104, 60) | 0.59 | 9 (−72, 90) | 0.82 | 15 (−68, 99) | 0.71 | −38 (−137, 61) | 0.44 |
| Luteal Pd3G AUC 5 (μg/mg creatinine) | 104 (69) | −10 (−48, 28) | 0.59 | 25 (−3, 53) | 0.08 | 0 (−28, 27) | 0.98 | 27 (−3, 57) | 0.08 | 21 (−14, 56) | 0.23 |
| Ovulatory cycles (%) | 90.0 (30.5) | 9.9 (−2.4, 22.3) | 0.11 | 10.0 (−0.4, 20.5) | 0.06 | 10.1 (0.2, 20.0) | 0.05 | 10.0 (−0.5, 20.8) | 0.06 | 0.1 (−13.1, 13.3) | 0.98 |
| Creatinine (mg/ml) | 1.13 (0.35) | 1.16 (0.87, 1.46) | <0.001 | 0.94 (0.64, 1.24) | <0.001 | 0.58 (0.27, 0.89) | <0.001 | 0.40 (0.08, 0.72) | 0.02 | 0.13 (−0.23, 0.49) | 0.47 |
CI, Confidence interval; AUC, area under the curve.