Fig. 1.

KEGG functional profiling and interaction modules, illustrating transcriptomic interactions in FCHL adipocytes. A, Functional profiling depicts significantly overrepresented KEGG pathways on the basis of differentially expressed genes in FCHL vs. control adipocytes. Functional profiling was conducted via the FunNet tool by considering all differentially expressed genes at an FDR of 5%. Transcriptional domain coverage for each pathway corresponds to the percentage of the transcriptional domain covered by the genes identified for that pathway. Up- and down-regulated pathways are shown separately. B, Functional themes, represented by enriched KEGG pathways, were correlated in a proximity interaction network driven by the expression similarity of their annotated genes. KEGG categories are indicated by nodes, whereas transcriptional interactions among the KEGG categories are indicated by edges. Continuous lines indicate stronger, whereas dashed lines depict medium-strength, interactions.