Table 3.
Amino acid variations in the docking of Lep and LepR for multiple species compared to human
| Lep Amino acid variations in the binding with LepR | LepR Amino acid variations in the binding with Lep | Binding Energy (KJ/mol) | |
|---|---|---|---|
| Human | - | 1979.66 | |
| Sumatran orangutan | - | - | 1979.66 |
| Common Chimpanzee | - | - | 1979.66 |
| Northern White-Cheeked Gibbon | - | - | 1979.66 |
| Rhesus macaque | D29S, V110L | Y11H, L186S | 1648.24 |
| Crab-Eating Macaque | D29S, V110L | Y11H, L186S | 1648.24 |
| Giant Panda | V110L, F113S | L100V | 1976.03 |
| Horse | V110L, F113S | L100V, L186Q | 1960.17 |
| Sheep | V110L, F113A | L100I | 1976.91 |
| Cattle | V110L, F113A | L100I, R185S | 1968.73 |
| Little Brown Bat | R92G, V110L, F113S | L100V, V132I | 2199.13 |
| Ferret | incomplete sequence | L100V | - |
| European Rabbit | N43S, V110L, F113S | - | 1975.9 |
| African elephant | N43S, V110L, F113A | L100V | 1969.57 |
| Pig | K26R, N43S, V110L, F113S | L100I | 1977.58 |
| Grey Seal | K26R, E102A, D106A, V110L, F113S | L100V, V132I | 1404.81 |
| Common Marmoset | K26R, T40A, R92G, D106A, V110L, F113A | Y11S, S40R, D102N, K130N, N136T | 2500.01 |
| Dog | T40A, V110L, F113S | L100V | 1968.61 |
| Chinese hamster | V110L, F113S | - | 1976.03 |
| Naked Mole rat | T40S, E102D, D106N, V110M, F113S | Q71K, N137K | 2217.13 |
| Guinea Pig | V27L, T33F, T40N, N43R, R92S, D106S, V110M, F113S | L76F, L100T, S102A, K130T, V132S, P134S, N137Q | 1711.5 |
| Rat | R92Q, N99H, V110L | - | 2211.09 |
| Mouse | R92Q, V110L | - | 2186.01 |
| Platypus | V27I, D29A, N43I, R92P, D106S, V110L, F113T | F74Y, L100V, K130R, V132T, N137H | 1477.96 |
| Mallard | R92Q, N99D, V110L | S40K, L41I, F74S, L100V, D102A, S103D, K130N, P134T, E135N, N136D, N137D, R185A | 2146.29 |
| Chicken | K26I, V27F, R92Q, V110L | R38M, S40K, L41I, L100V, D102A, S103D, K130N, P134T, E135N, N136D, N137D, R185A | 1055.16 |
| Wild Turkey | K26I, V27F, R92Q, V110L | S40K, L41I, L100V, D102A, S103D, K130N, P134A, E135N,N136D, N137D, R185A | 1685.26 |
| Green anole | V27T, D29A, T33M, K36R, T40S, N43Q,R92E, N99Y, D106S, V110L, F113A | Y11N, T13Q, L41V, F74Y, D102K, K130N, V132E, E135K, N136Y, N137D, R185L, L186T | 1403.94 |
| Western Clawed Frog | K26R, D29N, T33M, K36R, N40Q, R92E, N99S, D106S | Y11N, L12Q, T13K, Q71E, F74H, L76V, D102I, K130R, V132A, F133L, E135S, N136T, N137D, L186T | 1869.87 |