Table 3.

Effect of Age on Tacrolimus and Cyclosporine Trough Concentrations (median, IQR)

Age group	Young (18–34 years)	Middle (35–64 years)	Old (65–84 years)
Tacrolimus
No. subjects	266	1425	276
No. troughs	4374	25194	4911
TAC trough (ng/mL)	7.8(5.8–10.0)	8.1(6.1–10.1)	8.2(6.4–10.3)
TAC daily dose (mg)	7.0(4.0–10.0)	6.0(4.0–8.0)	5.0(3.0–8.0)
Weight (kg)	71.8(60.0–89.2)	81.6(70.2–95.3)	81.0(69.7–93.5)
TAC dose-and weight-normalized trough	77.1(48.5–127.0)	111.4(68.9–180.0)	129.8(84.5–201.2)
Cyclosporine
No. subjects	107	520	117
No. troughs	1666	7687	1779
CSA trough (ng/mL)	169.0(133.0–222.0)	179.0(139.0–228.0)	181.0(139.0–233.0)
CSA daily dose (mg)	350(300–450)	350(250–400)	250(200–350)
Weight (kg)	69.3(60.9–87.5)	83.1(70.3–98.2)	78.2(65.9–89.9)
CSA dose and weight normalized trough	34.6(24.1–51.4)	46.7(33.0–65.2)	54.6(39.9–74.1)

TAC, tacrolimus; CSA, cyclosporine

Data are median and interquartile range (IQR)