Table 1.
Characteristics of the analysis population by islet autoimmunity (IA) status.
| Characteristic | Children positive for IA n = 111 |
Children negative for IA n = 1570 |
Univariate HR and 95% CI | p-Value |
|---|---|---|---|---|
| Mean agea (years) | 5.5 (3.8) | 9.1 (5.6) | N/A | N/A |
| HLA-DR3/4, DQB1*0302 | 34 (30.6%) | 274 (17.5%) | 2.18 (1.45, 3.26) | 0.0002 |
| First degree relative with type 1 diabetes | 67 (60.4%) | 652 (41.5%) | 1.66 (1.13, 2.43) | 0.01 |
| Ethnicity (non-Hispanic white) | 90 (81.1%) | 1120 (71.3%) | 1.38 (0.85, 2.25) | 0.20 |
| Sex (female) | 53 (47.8%) | 730 (46.5%) | 1.07 (0.75, 1.54) | 0.71 |
| VDR rs1544410 (AA/AG) | 76 (68.5%) | 959 (61.1%) | 1.32 (0.90, 1.95) | 0.16 |
| VDR rs2228570 (AA/AG) | 69 (62.2%) | 955 (60.8%) | 0.99 (0.68, 1.45) | 0.98 |
| VDR rs11568820 (TT/TC) | 36 (32.4%) | 630 (40.1%) | 0.72 (0.49, 1.07) | 0.11 |
| PTPN2 rs1893217 (GG/GA) | 39 (35.1%) | 438 (27.9%) | 1.34 (0.90, 1.99) | 0.15 |
| PTPN2 rs478582 (CC/CT) | 78 (70.3%) | 1077 (68.6%) | 1.08 (0.72, 1.62) | 0.72 |
a
Age at first IA positive visit in autoantibody positive children or age at last follow-up in autoantibody negative children.