. Author manuscript; available in PMC: 2013 Jan 1.

Published in final edited form as: J Steroid Biochem Mol Biol. 2012 Sep 7;133:51–57. doi: 10.1016/j.jsbmb.2012.08.012

Table 2.

Association between variants in VDR and PTPN2 and risk of islet autoimmunity (n = 111 affecteds and 1570 unaffecteds).

Variable	HR	95% CI	p-Value
Model of VDR Variants
VDR rs1544410 (AA/AG vs. GG)	1.39	0.94, 2.07	0.10
VDR rs2228570 (AA/AG vs. GG)	0.99	0.68, 1.45	0.96
VDR rs11568820 (TT/TC vs. CC)	0.73	0.49, 1.10	0.13
Model of PTPN2 Variants
PTPN2 rs1893217 (GG/GA)	1.36	0.90, 2.04	0.15
PTPN2 rs478582 (CC/CT)	1.23	0.80, 1.87	0.35

In the Model of VDR variants, the three VDR SNPs were included in a single model, adjusting for HLA-DR3/4, DQB1*0302 genotype, first degree relative with type 1 diabetes, and non-Hispanic white ethnicity. Likewise, in the Model of PTPN2 variants, the two PTPN2 SNPs were included in a single model, adjusting for HLA-DR3/4, DQB1*0302 genotype, first degree relative with type 1 diabetes, and non-Hispanic white ethnicity.