Table 3.
Characteristics of islet autoantibody (IA) positive subjects by type 1 diabetes (T1D) status.
| Characteristic | IA positive children who progressed to T1D n = 38 |
IA positive children who have not progressed to T1D n = 84 |
Univariate HR and 95% CI | p-Value |
|---|---|---|---|---|
| Mean agea (years) | 8.2 (4.0) | 12.8 (4.6) | N/A | N/A |
| Mean age at first IA positive visit (years) | 3.6 (2.9) | 6.1 (3.8) | 0.88 (0.78, 0.98) | 0.03 |
| HLA-DR3/4, DQB1*0302 | 23 (60.5%) | 14 (16.7%) | 3.98 (2.13, 7.41) | <.0001 |
| First degree relative with T1D | 26 (68.4%) | 52 (61.9%) | 1.11 (0.57, 2.17) | 0.76 |
| Ethnicity (non-Hispanic white) | 35 (92.1%) | 66 (78.6%) | 1.95 (0.57, 6.62) | 0.29 |
| Sex (female) | 20 (52.6%) | 37 (44.1%) | 1.47 (0.76, 2.85) | 0.26 |
| VDR rs1544410 (AA/AG) | 24 (63.2%) | 57 (67.9%) | 0.67 (0.34, 1.29) | 0.23 |
| VDR rs2228570 (AA/AG) | 18 (47.4%) | 56 (66.7%) | 0.63 (0.34, 1.17) | 0.14 |
| VDR rs11568820 (TT/TC) | 14 (36.8%) | 30 (35.7%) | 1.37 (0.70, 2.71) | 0.36 |
| PTPN2 rs1893217 (GG/GA) | 12 (31.6%) | 31 (36.9%) | 0.77 (0.40, 1.48) | 0.43 |
| PTPN2 rs478582 (CC/CT) | 28 (73.7%) | 57 (67.9%) | 1.23 (0.61, 2.45) | 0.57 |
a
Age at T1D diagnosis in diabetic children or age at last follow-up in non-diabetic children.