Table 4.
PON1 genotype | N | CPOase (U/l) | POase (U/l) | ||
---|---|---|---|---|---|
Baseline | Post CPF exposure | Baseline | Post CPF exposure | ||
QQ/LL | 11 | 4196 (2854 – 5982) | 4601 (2977 – 7030) | 54 (36 – 86) | 58 (36 – 81) |
QQ/LM | 9 | 3552 (2010 – 5494) | 3779 (1606 – 6607) | 47 (24 – 63)a,b | 46 (18 – 87)a,b |
QQ/MM | 5 | 2411 (1941 – 2842)a,b,c | 2982 (2380 – 3992) | 38 (31 – 42)a,b,d | 38 (32 – 46)a,b,e |
QR/LL | 11 | 4593 (1966 – 6348) | 4024 (1858 – 5277) | 100 (61 – 149)c | 88 (59 – 124)c |
QR/LM | 15 | 3455 (2262 – 5053)a | 3478 (2152 – 4924) | 94 (56 – 132)b,c,e | 85 (61 – 121)b,c,e |
QR/MM | 3 | 1860 (1286 – 2345)a,b,c | 1727 (1329 – 2474)a,b,c | 57 (46 – 77)b | 47 (32 – 69)a,b,e |
RR/LL | 12 | 3909 (2269 – 4643) | 4170 (2680 – 5301) | 136 (59 – 171)a,c | 132 (101 – 173)a,c |
RR/LM | 1 | 1592 | 1507 | 78 | 42 |
RR/MM | 0 | - | - | - | - |
Data expressed as the mean (range). P-value compares CPOase or POase activity among the different genotypes for the same time period using ANOVA with Tukey post-hoc test.
P ≤ 0.05 compared to QRLL genotype.
P ≤ 0.05 compared to RRLL genotype.
P ≤ 0.05 compared to QQLL genotype.
P ≤ 0.05 compared to QRLM genotype
P ≤ 0.05 compared to QQLM genotype.