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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Bone. 2012 Oct 5;52(1):212–219. doi: 10.1016/j.bone.2012.09.035

Fig. 3. Anti-angiogenic Treatment Reduced Vessel Count and Volume 7 days after Loading.

Fig. 3

(A) H&E stained cross-section of an ulna 3 days after loading, with bone labeled B, muscle labeled M, perfused vessels black, and the expanded periosteum marked with a double-headed arrow. Scale bar is 250 µm. (B) Quantification of vessel number in histological sections showed significantly fewer vessels in nanoparticle treated limbs (black) than vehicle (white) 7 days after loading. (C) MicroCT reconstruction of the midsection of the ulna (grey) with surrounding perfused vasculature (red). (D) Quantification of microCT images showed significantly less vessel volume in nanoparticle treated limbs (black) than vehicle (white) 7 days after loading. All values are mean ± standard deviation. * p < 0.05 vs. Vehicle.