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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Bone. 2012 Oct 5;52(1):212–219. doi: 10.1016/j.bone.2012.09.035

Fig. 5. Anti-Angiogenic Treatment Reduces the Early Increase in CD105 Positive Blood Vessels and the Later Increase in αSMA Positive Blood Vessels after Loading.

Fig. 5

Immunohistochemistry staining for (A) CD105 and (C) αSMA is quantified (B, D) for nanoparticle treated loaded limbs, vehicle treated loaded limbs, and non-loaded limbs. On day 3, treatment significantly reduced the number of CD105 positive blood vessels. By day 7, this resulted in a significant decrease in the number of αSMA positive blood vessels. Perfused vessels appear black, and arrows indicate positively stained vessels. Scale bar is 250 µm. *: p < 0.05 vs. Non-Loaded, †: p < 0.05 vs. Vehicle.