Table 1.

Common genetically-engineered pigs currently available for biomedical research

Knock-out technology for deletion of antigen expression

- GTKO (α1,3-galactosyltransferase gene-knockout)

Knock-in technology for human complement regulation

- human CD46

- human CD55

- human CD59

Knock-in technology for human thromboregulation

- human CD39

- human thrombomodulin (TBM)

- human endothelial protein c receptor (EPCR)

Pigs with multiple gene modifications exist (e.g., GTKO.hCD46.hCD55 or GTKO.hCD46.hTBM or GTKO.hCD55.hCD59.hCD39.hTBM)