Table 7.
Comparison of normal GTKO and WT pig mean values with 4 primate species
| Test | Unit | GTKO* | WT* | Baboon | Cyno* | Rhesus* | Human | |
|---|---|---|---|---|---|---|---|---|
| Hematology | WBC | /mm3 | 15.5 | 18.6 | 10.0 | 11.9 | 8.0 | 3.8 – 10.6 |
| RBC | ×106/mm3 | 6.3 | 6.9 | 5.1 | 5.8 | 5.6 | 3.73 – 4.89 | |
| Hemoglobin | g/dL | 12.2 | 10.0 | 12.7 | 13.0 | 13.2 | 11.6 – 14.6 | |
| Hematocrit | % | 37.9 | 37.9 | 39.9 | 43.1 | 40.9 | 34.1 – 43.3 | |
| Platelets | ×103/mm3 | 425.0 | 506.6 | 419.2 | 431.7 | 359.0 | 156 – 369 | |
| MCV | fL | 61.3 | 58.7 | 77.2 | 74.6 | 74.4 | 82.6 – 97.4 | |
| MCH | pg | 19.7 | 17.4 | 25.1 | 22.7 | 23.7 | 27.8 – 33.4 | |
| MCHC | g/dL | 32.3 | 25.5 | 32.6 | 30.7 | 32.0 | 32.7 – 35.5 | |
| RDW | % | 21.4 | 19.0 | 13.1 | 13.7 | 13.0 | 11.8 – 15.2 | |
| MPV | fL | 9.1 | n.a. | 8.5 | 9.0 | n.a. | 6.8 – 10.4 | |
| Neutrophil | % | 41.8 | 45.6 | 52.0 | 33.2 | 54.3 | 44 – 77 | |
| Lymphocyte | % | 49.1 | 45.5 | 44.4 | 58.4 | 38.2 | 13 – 44 | |
| Monocyte | % | 4.9 | 4.7 | 3.2 | 4.4 | 3.5 | 4 – 13* | |
| Eosinophil | % | 2.3 | 1.9 | 0.9 | 2.6 | 3.1 | 0 – 6 | |
| Basophil | % | 0.1 | 0.4 | 0.3 | 0.7 | 0.2 | 0 – 1 | |
| Renal Function and Electrolytes | Sodium | mmol/L | 144.0 | 142.9 | 146.1 | 158.4 | 147.3 | 136 – 146 |
| Potassium | mmol/L | 5.3 | 5.3 | 3.8 | 5.8 | 4.0 | 3.5 – 5.0 | |
| Chloride | mmol/L | 103.0 | 104.8 | 108.0 | 113.4 | 112.6 | 95 – 110 | |
| Calcium | mg/dL | 10.8 | 11.0 | 9.5 | 11.1 | 9.4 | 8.4 – 10.2 | |
| Phosphorus | mg/dL | 8.8 | 8.6 | 4.3 | 5.6 | 4.1 | 2.5 – 4.5 | |
| CO2 | mmol/L | 28.1 | 29.0 | 22.9 | n.a. | 13.9 | 21–32 | |
| Urea | mg/dL | 12.8 | 12.4 | 14.3 | 23.1 | 17.3 | 5.0 – 20.0 | |
| Creatinine | mg/dL | 1.1 | 1.0 | 0.7 | 0.8 | 1.0 | 0.6 – 1.1 | |
| Liver Function | AST | IU/L | 37.0 | 40.1 | 36.6 | 33.1 | 33.6 | < 40 |
| ALT | IU/L | 42.0 | 58.5 | 39.2 | 47.1 | 44.6 | < 40 | |
| ALP | IU/L | 272.0 | 263.1 | 637.7 | 1138.6 | 183.7 | 38 – 126 | |
| LDH | IU/L | 472.0 | 825.9 | 284.2 | 598.8 | 311.0 | < 170 | |
| GGT | IU/L | 74.0 | 43.0 | 39.0 | 124.1 | 61.0 | < 40 | |
| Tot Bilirubin | mg/dL | 0.2 | 0.5 | 0.1 | 0.3 | 0.4 | 0.3 – 1.5 | |
| Dir Bilirubin | mg/dL | 0.1 | 0.1 | 0.1 | 0.1 | 0.7 | 0.1 – 0.4 | |
| Indir Bilirubin | mg/dL | 0.1 | 0.1 | 0.1 | n.a. | 2.1 | 0.2 – 1.1 | |
| Tot Protein | g/dL | 5.9 | 5.2 | 6.8 | 7.9 | 7.1 | 6.3 – 7.7 | |
| Albumin | g/dL | 3.4 | 2.6 | 4.1 | 4.3 | 4.0 | 3.4 – 5.0 | |
| Cholesterol | mg/dL | 81.0 | 100.6 | 103.2 | 131.5 | 141.7 | <200 | |
| Triglyceride | mg/dL | 31.0 | 57.5 | 60.1 | 44.8 | 75.3 | <150 | |
| Glucose | mg/dL | 89.0 | 92.1 | 96.4 | 81.0 | 67.1 | 70 – 99 | |
| Coaulation Profile | PT | sec | 13.6 | 11.7 | 14.3 | 9.4 | 14.2 | 11.3 – 14.5 |
| PTT | sec | 34.1 | 15.5 | 32.6 | 21.6 | 43.0 | 22.7 – 35.6 | |
| INR | 1.1 | n.a. | 1.3 | n.a. | n.a. | 0.8 – 1.2 | ||
| D-Dimer | μg/mL | 0.2 | n.a. | 0.7 | n.a. | n.a. | <0.45 | |
| FDP | μg/mL | 5to20 | n.a. | <5 | n.a. | n.a. | <5 neg, >20 pos | |
| Fibrinogen | mg/dL | 250.0 | n.a. | 189.5 | 235.8 | n.a. | 200 – 400 | |
| Others | Amylase | IU/L | 1622.0 | n.a. | 185.7 | 440.0 | n.a. | 35 – 118 |
| Lipase | IU/L | 13.1 | n.a. | 29.8 | n.a. | n.a. | 22 – 51 | |
| Iron | μg/dL | 104.0 | 175.2 | 158.9 | 156.3 | 156.0 | 28 – 170 | |
| Total CPK | IU/L | 1166.0 | n.a. | n.a. | n.a. | n.a. | 60 – 400 | |
| CPK-MB isoenzyme | ng/mL | 4.4 | n.a. | n.a. | n.a. | n.a. | 0 – 3 | |
| CPK-MB relative index | 0.7 | n.a. | n.a. | n.a. | n.a. | 0 – 3 | ||
| Troponin I | ng/mL | 0.1 | n.a. | n.a. | n.a. | n.a. | < 0.4 |
*
GTKO = α1,3-galactosyltransferase gene-knockout pigs; WT = wild-type pigs; Cyno = cynomolgus monkeys; Rhesus = rhesus monkeys. n.a. = not available. GTKO values indicated in bold are statistically different from human values.