TABLE II. Table II. Published placebo-controlled studies of antipsychotics for irritability. Dx, diagnosis; AUT, austistic disorder; PDD, pervasive developmental disorder not otherwise specified; PLA, placebo; RUPP, Research Units on Pediatric Psychopharmacology; ABC-I, Aberrant Behavior Checklist Irritability subscale; all ages are in years.

Study	Drug	Subjects	Design	Results
Campbell et al, 197852	haloperidol	N = 40	10 weeks	haloperidol > PLA
		Age = 2 - 7	Parallel groups
		Dx = AUT
Cohen et al, 198053	Haloperidol	N = 10	2 weeks	haloperidol > PLA
		Age = 2 - 7	Crossover
		Dx = AUT
Anderson et al, 198454	Haloperidol	N = 40	4 weeks	Haloperidol > PLA
		Age = 2 - 7	Crossover
		Dx = AUT
Naruse et al, 198283	Pimozide	N = 87	8 weeks	Pimozide > PLA
	Haloperidol	Age = 3 - 16	Crossover	haloperidol > PLA
		Dx = AUT, PDD		Pimozide = Haloperidol
McCracken et al, 200269	Risperidone	N = 101	8 weeks	Risperidone > PLA
		Age = 5 - 17	Parallel groups	34/49 (69%) responders;
		Dx = AUT		(57%) improvement on ABC-I
Shea et al, 200470	Risperidone	N = 79	8 weeks	Risperidone (64%) > PLA (31%)
		Age = 5 - 12	Parallel groups	improvement on ABC-I
		Dx = AUT, PDD
McDougle et al, 199878	Risperidone	N = 31	12 weeks	Rispendone > PLA
		Age = 18 - 43	Parallel groups	8/14 (57 %) responders
		Dx = AUT, PDD
Hollander et al, 200687	Olanzapine	N = 11	8 weeks	Olanzapine > PLA
		Age = 6 - 17	Parallel groups	6/11 (55%) responders
		Dx = AUT, ASP, PDD
Marcus et al, 200997	Aripiprazole	N = 218	8 weeks	Aripiprazole > PLA on ABC-I
		Age = 6 -17	Parallel groups
		Dx = AUT
Owen et al, 200998	Aripiprazole	N = 98	8 weeks	Aripiprazole > PLA
		Age = 6 - 17	Parallel groups	(52%) responders
		Dx = AUT