Table I. Autism-relevant behavoral phenotypes in selected mouse models with targeted mutations in associated with autism.^155-169.

	Gene	Protein	Autism-relevant behavoral phenotypes
	Integrin β3	Integrin β3	Lack of preference for social novelty
			Increased repetitive self-grooming
	Nign1	Neuroligin 1	Increased repetitive self-grooming
	Nign2	Neuroligin 2	Increased repetitive self-grooming
Synaptic	Nign3	Neuroligin 3	Reduced pup ultrasonic vocalizations
cell-adhesion			Sensory abnormalities
proteins	Nign4	Neuroligin 4	Reduced sociability and vocalizations
	Neurexin-1α	Neurexin-1α	Increased repetitive self-grooming
	Cntnap2	Contactin-associated protein2	Seizures, reduced social behaviors
	Shank3	Shank3	Mild reduction in social interactions and adult vocalizations
.
	En2	Engrailed-2	Reduced social behaviors - Impaired learning and memory
Signaling and	Met	Tyrosine kinase/ hepatocyte	Cognitive deficit
developmental		growth factor receptor
proteins	Foxp2	Forkhead box protein 2	Reduced pup ultrasonic vocalizations
	Pten	Phosphatase and tensin homolog	Reduced reciprocal social interactions - Reduced sociability
.
	Avrp1	Vasopressin receptor	Impaired social recognition - Reduced reciprocal social interaction
			Reduced ultrasonic vocalizations
	Cadps2	Calcium-dependent secretion	Reduced reciprocal social interactions
Neurotransmitters		activator 2
and receptors	Gabrb3	GABA A receptor beta3 subunit	Low sociability - Lack of preference for social novelty
			Repetitive stereotyped circling behavior
	Oxtr	Oxytocin receptor	Impaired social gecognition - Reduced pup ultrasonic vocalizations
	Slc6a4	Solute carrier family 6, member 4	Low sociability
		(Serotonin transporter)	Lack of preference for social novelty