Table 2.

Adjusted Odds Ratios (ORs) and 95% Confidence Intervals (95% CI) for NHL risk according to height and BMI 2 years prior to diagnosis and at age 18; Mayo Case-Control Study of NHL, 2002–2008

				All NHL			FL
Variable, level		Cut point Value	Controls	Cases	Odds Ratio*	95% CI	Cases	Odds Ratio*	95% CI
Recent Adult BMI (2 years prior to case diagnosis / control enrollment)
	<18.5		13	8	0.85	0.34–2.09	3	1.08	0.30–3.89
	18.5–24.9		353	276	1	Reference	80	1	Reference
	25.0–29.9		466	378	0.96	0.78–1.18	85	0.75	0.54–1.06
	30.0+		286	273	1.15	0.91–1.45	73	1.07	0.75–1.52
	P-trend				0.23			0.84
males	18.5–24.9		118	115	1	Reference	29	1	Reference
	25.0–29.9		302	254	0.87	0.64–1.18	56	0.75	0.46–1.24
	30.0+		174	174	1.03	0.74–1.44	38	0.89	0.52–1.52
	P-trend				0.73			0.75
females	<18.5		13	8	0.89	0.36–2.23	3	1.06	0.29–3.90
	18.5–24.9		235	161	1	Reference	51	1	Reference
	25.0–29.9		164	124	1.05	0.77–1.43	29	0.76	0.46–1.26
	30.0+		112	99	1.27	0.90–1.78	35	1.41	0.86–2.30
	P-trend				0.17			0.31
	P-interaction+				0.53			0.37
Early Adult BMI (at age 18)
	Quartile 1		289	214	1	Reference	63	1	Reference
	Quartile 2	Uses gender specific cut- points below	282	188	0.88	0.68–1.14	49	0.79	0.53–1.20
	Quartile 3		275	245	1.2	0.94–1.54	56	0.95	0.64–1.41
	Quartile 4		282	287	1.38	1.08–1.76	72	1.18	0.81–1.73
	P-trend				0.0012			0.27
males	Quartile 1	<=20.94	157	145	1	Reference	41	1	Reference
	Quartile 2	20.95–22.49	145	100	0.7	0.49–0.98	22	0.56	0.32–0.98
	Quartile 3	22.5–24.37	149	133	0.91	0.66–1.27	26	0.65	0.38–1.11
	Quartile 4	>24.37	150	162	1.1	0.80–1.52	34	0.84	0.50–1.39
	P-trend				0.31			0.55
females	Quartile 1	<=18.97	132	69	1	Reference	22	1	Reference
	Quartile 2	18.98–20.39	137	88	1.22	0.82–1.83	27	1.17	0.63–2.16
	Quartile 3	20.4–22.33	126	112	1.74	1.18–2.58	30	1.45	0.79–2.66
	Quartile 4	>22.33	132	125	1.9	1.29–2.79	38	1.81	1.01–3.25
	P-trend				0.00025			0.029
	P-interaction+				0.097			0.18

				CLL/SLL			DLBCL
Variable, level		Cut point Value	Controls	Cases	Odds Ratio*	95% CI	Cases	Odds Ratio*	95% CI	DF^	p- value^
Recent Adult BMI (2 years prior to case diagnosis / control enrollment)
	<18.5		13	1	0.36	0.05–2.82	2	1.14	0.25–5.22
	18.5–24.9		353	83	1	Reference	49	1	Reference
	25.0–29.9		466	127	1.05	0.76–1.43	69	1.03	0.69–1.53
	30.0+		286	87	1.19	0.85–1.68	55	1.35	0.89–2.04
	P-trend				0.22			0.18		3	0.71
males	18.5–24.9		118	39	1	Reference	16	1	Reference
	25.0–29.9		302	89	0.9	0.58–1.39	42	1.02	0.55–1.88
	30.0+		174	62	1.08	0.68–1.72	33	1.39	0.73–2.64
	P-trend				0.66			0.25		3	0.62
females	<18.5		13	1	0.41	0.05–3.20	2	1.1	0.24–5.11
	18.5–24.9		235	44	1	Reference	33	1	Reference
	25.0–29.9		164	38	1.19	0.73–1.92	27	1.12	0.65–1.94
	30.0+		112	25	1.17	0.68–2.02	22	1.38	0.76–2.47
	P-trend				0.35			0.32		3	0.95
	P-interaction+				0.63			0.94
Early Adult BMI (at age 18)
	Quartile 1		289	70	1	Reference	35	1	Reference
	Quartile 2	Uses gender specific cut- points below	282	54	0.77	0.52–1.14	34	0.99	0.60–1.64
	Quartile 3		275	86	1.29	0.90–1.84	47	1.43	0.89–2.28
	Quartile 4		282	87	1.27	0.89–1.82	60	1.77	1.13–2.77
	P-trend				0.04			0.0040		3	0.47
males	Quartile 1	<=20.94	157	49	1	Reference	22	1	Reference
	Quartile 2	20.95–22.49	145	29	0.58	0.34–0.97	15	0.74	0.37–1.49
	Quartile 3	22.5–24.37	149	53	1.05	0.67–1.65	21	1.01	0.53–1.92
	Quartile 4	>24.37	150	57	1.11	0.71–1.74	33	1.57	0.87–2.83
	P-trend				0.26			0.078		3	0.28
females	Quartile 1	<=18.97	132	21	1	Reference	13	1	Reference
	Quartile 2	18.98–20.39	137	25	1.18	0.63–2.22	19	1.39	0.66–2.94
	Quartile 3	20.4–22.33	126	33	1.78	0.97–3.25	26	2.11	1.04–4.31
	Quartile 4	>22.33	132	30	1.52	0.82–2.80	27	2.16	1.06–4.38
	P-trend				0.093			0.017		3	0.72
	P-interaction+				0.48			0.4

^*All models adjusted for age at enrollment, gender, and county of residence.

^{^}DF for the test of heterogeneity across the subtypes; note that these associated p-values are testing whether the trend differs across the three main subtypes and "other" subtypes.

⁺p-value for the test of statistical interaction between gender and physical activity.