Table 3.

Adjusted Odds Ratios (ORs) and 95% Confidence Intervals (95% CI) for NHL risk according to Physical Activity level at different life stages; Mayo Case-Control Study of NHL, 2002–2008

				ALL NHL			FL
Variable	Level	Cut Point Value	Controls	Cases	Odds Ratio^*	95% CI	Cases	Odds Ratio^*	95% CI
Recent Adult Physical Activity (2 Years Prior to enrollment)
Total Met-minutes/week at diagnosis	Quartile 1	<615 Mets/wk	268	218	1	Reference	55	1	Reference
	Quartile 2	616–1470 Mets/wk	270	237	1.09	0.85– 1.40	59	1.07	0.72–1.61
	Quartile 3	1471–2700 Mets/wk	267	200	0.92	0.71– 1.19	55	1.01	0.67–1.52
	Quartile 4	2701+ Mets/wk	266	219	1.03	0.80– 1.33	53	0.98	0.65–1.48
	P-trend				0.85			0.86
males	Quartile 1		172	142	1	Reference	34	1	Reference
	Quartile 2		144	129	1.09	0.79– 1.52	30	1.05	0.61–1.80
	Quartile 3		141	114	0.95	0.68– 1.33	27	0.95	0.55–1.65
	Quartile 4		117	131	1.37	0.98– 1.92	22	0.96	0.53–1.72
	P-trend				0.15			0.82
females	Quartile 1		96	76	1	Reference	21	1	Reference
	Quartile 2		126	108	1.06	0.71– 1.58	29	1.03	0.55–1.92
	Quartile 3		126	86	0.84	0.55– 1.26	28	0.97	0.52–1.83
	Quartile 4		149	88	0.71	0.47– 1.07	31	0.9	0.49–1.67
	P-trend				0.039			0.70
	p-interaction⁺				0.059			0.99
Early Adult Physical Activity
Strenuous activity at age 18	Never		316	274	1	Reference	73	1	Reference
Strenuous activity at age 18	Ever		708	578	0.88	0.72– 1.07	153	0.91	0.67–1.24
males	Never		97	85	1	Reference	17	1	Reference
	Ever		465	414	1.00	0.73– 1.39	96	1.17	0.67–2.05
females	Never		219	189	1	Reference	56	1	Reference
	Ever		243	164	0.81	0.61– 1.07	57	0.96	0.64–1.46
	p-interaction⁺				0.30			0.52

				CLL/SLL			DLBCL
Variable	Level	Cut Point Value	Controls	Cases	Odds Ratio^*	95% CI	Cases	Odds Ratio^*	95% CI	DF^{^}	p-value^{^}
Recent Adult Physical Activity (2 Years Prior to enrollment)
Total Met-minutes/week at diagnosis	Quartile 1	<615 Mets/wk	268	69	1	Reference	40	1	Reference
	Quartile 2	616–1470 Mets/wk	270	66	0.96	0.66–1.40	49	1.22	0.78–1.91
	Quartile 3	1471–2700 Mets/wk	267	70	1.01	0.70–1.47	39	0.98	0.61–1.57
	Quartile 4	2701+ Mets/wk	266	73	1.09	0.75–1.58	39	0.99	0.62–1.59
	P-trend				0.60			0.72		3	0.82
males	Quartile 1		172	48	1	Reference	26	1	Reference
	Quartile 2		144	40	1.01	0.62–1.62	21	0.96	0.52–1.78
	Quartile 3		141	41	1.01	0.62–1.62	20	0.94	0.50–1.75
	Quartile 4		117	55	1.71	1.08–2.70	21	1.19	0.64–2.21
	P-trend				0.032			0.67		3	0.36
females	Quartile 1		96	21	1	Reference	14	1	Reference
	Quartile 2		126	26	0.93	0.49–1.76	28	1.5	0.75–3.01
	Quartile 3		126	29	1.06	0.57–1.98	19	1	0.48–2.10
	Quartile 4		149	18	0.53	0.27–1.06	18	0.8	0.38–1.69
	P-trend				0.10			0.2442		3	0.59
	p-interaction⁺				0.01			0.37
Early Adult Physical Activity
Strenuous activity at age 18	Never		316	86	1	Reference	54	1	Reference
	Ever		708	186	0.87	0.65–1.17	99	0.8	0.55–1.14	3	0.93
males	Never		97	32	1	Reference	15	1	Reference
	Ever		465	145	0.92	0.59–1.44	65	0.9	0.49–1.65	3	0.87
females	Never		219	54	1	Reference	39	1	Reference
	Ever		243	41	0.70	0.44–1.09	34	0.81	0.50–1.34	3	0.69
	p-interaction⁺				0.37			0.76

All models adjusted for age at enrollment, gender, and county of residence.

^{^}

DF for the test of heterogeneity across the subtypes; note that these associated p-values are testing whether the trend differs across the three main subtypes and "other" subtypes.

⁺

p-value for the test of statistical interaction between gender and physical activity.