Table 4.
NHL Overall | NHL Overall, Males only | NHL Overall, Females Only | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variables | Cases | Controls | OR | 95% CI | p-value | Cases | Controls | OR | 95% CI | p-value | Cases | Controls | OR | 95% CI | p-value | |
Model 1: Early Adult BMI and Physical Activity | ||||||||||||||||
BMI at age 18 | Quartile 1 | 188 | 265 | 1 | Reference | 0.00053 | 130 | 149 | 1 | Reference | 0.25 | 58 | 116 | 1 | Reference | 0.00016 |
Quartile 2 | 169 | 250 | 0.94 | 0.72–1.24 | 92 | 131 | 0.74 | 0.51–1.06 | 77 | 119 | 1.33 | 0.86–2.04 | ||||
Quartile 3 | 226 | 244 | 1.32 | 1.01–1.71 | 124 | 136 | 0.98 | 0.69–1.38 | 102 | 108 | 1.97 | 1.29–3.01 | ||||
Quartile 4 | 262 | 256 | 1.45 | 1.12–1.87 | 150 | 141 | 1.13 | 0.81–1.58 | 112 | 115 | 2.06 | 1.36–3.11 | ||||
Strenuous PA at age 18 | Never | 273 | 310 | 1 | Reference | 0.151 | 85 | 94 | 1 | Reference | 0.91 | 188 | 216 | 1 | Reference | 0.13 |
Ever | 572 | 705 | 0.86 | 0.71–1.06 | 411 | 463 | 0.98 | 0.71–1.36 | 161 | 242 | 0.8 | 0.60–1.07 | ||||
Model 2: Recent Adult BMI and Physical Activity | ||||||||||||||||
Adult BMI | <18.5 | 7 | 12 | 0.83 | 0.32–2.16 | 0.3 | 0 | 0 | NA | NA | 0.94 | 7 | 12 | 0.88 | 0.33–2.32 | 0.3 |
18.5–24.9 | 257 | 333 | 1 | Reference | 113 | 115 | 1 | Reference | 144 | 218 | 1 | Reference | ||||
25.0–29.9 | 346 | 435 | 0.94 | 0.75–1.17 | 238 | 281 | 0.86 | 0.62–1.17 | 108 | 154 | 0.97 | 0.69–1.35 | ||||
30.0+ | 249 | 265 | 1.13 | 0.89–1.44 | 158 | 162 | 0.99 | 0.70–1.39 | 91 | 103 | 1.23 | 0.85–1.77 | ||||
Adult PA | Quartile 1 | 213 | 259 | 1 | Reference | 0.93 | 140 | 166 | 1 | Reference | 0.14 | 73 | 93 | 1 | Reference | 0.062 |
Quartile 2 | 232 | 263 | 1.09 | 0.84–1.41 | 127 | 141 | 1.08 | 0.77–1.50 | 105 | 122 | 1.11 | 0.73–1.67 | ||||
Quartile 3 | 199 | 263 | 0.93 | 0.72–1.21 | 113 | 138 | 0.95 | 0.68–1.33 | 86 | 125 | 0.89 | 0.58–1.35 | ||||
Quartile 4 | 215 | 260 | 1.04 | 0.80–1.35 | 129 | 113 | 1.39 | 0.99–1.95 | 86 | 147 | 0.74 | 0.48–1.12 | ||||
Model 3: Early Adult and Recent Adult BMI | ||||||||||||||||
Adult BMI | <18.5 | 8 | 13 | 0.87 | 0.35–2.16 | 0.86 | 0 | 0 | NA | NA | 0.69 | 8 | 13 | 1.05 | 0.42–2.67 | 0.86 |
18.5–24.9 | 274 | 350 | 1 | Reference | 114 | 117 | 1 | Reference | 160 | 233 | 1 | Reference | ||||
25.0–29.9 | 376 | 463 | 0.9 | 0.72–1.12 | 253 | 300 | 0.84 | 0.61–1.16 | 123 | 163 | 0.97 | 0.70–1.33 | ||||
30.0+ | 270 | 285 | 0.98 | 0.76–1.25 | 171 | 174 | 0.91 | 0.63–1.31 | 99 | 111 | 1.06 | 0.73–1.54 | ||||
BMI at age 18 | Quartile 1 | 213 | 286 | 1 | Reference | 0.0019 | 144 | 157 | 1 | Reference | 0.18 | 69 | 129 | 1 | Reference | 0.0014 |
Quartile 2 | 188 | 280 | 0.88 | 0.68–1.14 | 100 | 144 | 0.72 | 0.51–1.01 | 88 | 136 | 1.21 | 0.81–1.81 | ||||
Quartile 3 | 243 | 272 | 1.21 | 0.94–1.56 | 132 | 146 | 0.96 | 0.68–1.34 | 111 | 126 | 1.69 | 1.13–2.52 | ||||
Quartile 4 | 284 | 273 | 1.41 | 1.08–1.83 | 162 | 144 | 1.19 | 0.84–1.69 | 122 | 129 | 1.82 | 1.20–2.77 | ||||
Model 4: Early Adult and Recent Adult Physical Activity | ||||||||||||||||
Adult PA | Quartile 1 | 188 | 234 | 1 | Reference | 0.68 | 122 | 155 | 1 | Reference | 0.10 | 66 | 79 | 1 | Reference | 0.15 |
Quartile 2 | 210 | 239 | 1.14 | 0.87–1.49 | 119 | 130 | 1.21 | 0.85–1.73 | 91 | 109 | 1.01 | 0.65–1.56 | ||||
Quartile 3 | 186 | 253 | 0.94 | 0.72–1.24 | 105 | 136 | 0.98 | 0.68–1.41 | 81 | 117 | 0.83 | 0.53–1.29 | ||||
Quartile 4 | 205 | 238 | 1.13 | 0.86–1.49 | 123 | 110 | 1.48 | 1.03–2.13 | 82 | 128 | 0.77 | 0.49–1.20 | ||||
Strenuous PA at age 18 | Never | 247 | 291 | 1 | Reference | 0.20 | 81 | 91 | 1 | Reference | 0.64 | 166 | 200 | 1 | Reference | 0.34 |
Ever | 542 | 673 | 0.87 | 0.70–1.08 | 388 | 440 | 0.92 | 0.65–1.30 | 154 | 233 | 0.86 | 0.64–1.17 | ||||
Model 5: Early Adult BMI and Recent Adult Physical Activity | ||||||||||||||||
BMI at age 18 | Quartile 1 | 191 | 263 | 1 | Reference | 0.0016 | 134 | 144 | 1 | Reference | 0.40 | 57 | 119 | 1 | Reference | 0.0003 |
Quartile 2 | 174 | 263 | 0.89 | 0.68–1.16 | 95 | 135 | 0.69 | 0.48–0.99 | 79 | 128 | 1.31 | 0.85–2.01 | ||||
Quartile 3 | 224 | 261 | 1.17 | 0.90–1.52 | 125 | 142 | 0.88 | 0.63–1.24 | 99 | 119 | 1.77 | 1.16–2.69 | ||||
Quartile 4 | 271 | 267 | 1.4 | 1.08–1.80 | 153 | 143 | 1.08 | 0.77–1.51 | 118 | 124 | 2.02 | 1.34–3.05 | ||||
Adult PA | Quartile 1 | 214 | 260 | 1 | Reference | 0.81 | 140 | 166 | 1 | Reference | 0.26 | 74 | 94 | 1 | Reference | 0.10 |
Quartile 2 | 235 | 267 | 1.1 | 0.85–1.42 | 128 | 142 | 1.09 | 0.78–1.53 | 107 | 125 | 1.09 | 0.72–1.64 | ||||
Quartile 3 | 197 | 264 | 0.92 | 0.71–1.20 | 112 | 139 | 0.92 | 0.66–1.30 | 85 | 125 | 0.89 | 0.58–1.37 | ||||
Quartile 4 | 214 | 263 | 1.03 | 0.79–1.33 | 127 | 117 | 1.31 | 0.93–1.85 | 87 | 146 | 0.76 | 0.50–1.16 |
N.B. Variable sizes differ by model due to missing values in the varying model covariates; all models adjusted for age at enrollment, gender, and county of residence; PA, physical activity.