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. Author manuscript; available in PMC: 2013 Dec 1.

Published in final edited form as: J Mol Recognit. 2012 Dec;25(12):642–656. doi: 10.1002/jmr.2221

Isothermal Titration Calorimetry measurement of drug-AGP binding interactions. Top panels show the heat in μcal/sec per injectant. Bottom panels show the enthalpy (kcal/mol) as a function of the drug-AGP molar ratio. All titrations were performed at 30°C. The insets show the stoichiometry (n), binding affinity (K_d) and thermodynamic parameters (ΔH°, enthalpy; TΔS°, entropy; ΔG°, free energy) for each interaction derived from a one site model fit of the binding isotherms. The chemical structure of each test compound is shown.

Isothermal Titration Calorimetry measurement of drug-AGP binding interactions. Top panels show the heat in μcal/sec per injectant. Bottom panels show the enthalpy (kcal/mol) as a function of the drug-AGP molar ratio. All titrations were performed at 30°C. The insets show the stoichiometry (n), binding affinity (K_d) and thermodynamic parameters (ΔH°, enthalpy; TΔS°, entropy; ΔG°, free energy) for each interaction derived from a one site model fit of the binding isotherms. The chemical structure of each test compound is shown.