Figure 2.

NSP-CAS signaling networks. The schematic diagram illustrates pathways discussed in the text, depicting how NSP proteins integrate CAS signaling downstream of integrins with signaling pathways downstream of other cell surface receptors. Signaling pathways downstream of cell surface receptors as well as many other known regulators and effectors of CAS family proteins are not shown. Overexpression of several NSP and CAS proteins has been implicated in cancer malignancy and resistance to chemotherapy, which may be due at least in part to perturbation of the signaling interactions shown in the figure.