Figure 3.

ABL1 and ABL2 fusions in cancer. Schematic domain representation of the proto-oncogene products of the ABL1 and ABL2 genes, as well as the known fusion gene products that mainly arise through chromosomal translocations. Known phosphorylation sites are indicated. The phosphorylation events on Tyr-177 in Bcr-Abl isoforms and Tyr-314 in Etv6-Abl that are discussed in more detail are indicated in red. Sizes of the proteins are approximately to scale. Domain abbreviations are as follows: TyrK, tyrosine kinase; FABD, F-actin binding; CC, coiled-coil; DH, Dbl-homolgy; PH, Pleckstrin-homology; RHOGAP, Rho GTPase-activating protein; WD40, Trp-Asp (W-D) terminating domain of ~40 amino acid length; PNT, pointed dimerization domain; RRM, RNA recognition motif.