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Apoptotic activation via the intrinstic pathway. Apoptotic stimuli activates the BH3-only proteins, concurrently inactivating Bcl-2 and activating Bax translocation to mitochondria. Bak is held in check by Mcl-1, VDAC2 and Bcl-xL. Bax/Bakoligomerisation results in cytochrome c release and MOMP. apaf-1 is activated by cytochrome c binding, displacing the CARD domain. The apoptosome forms with caspase-9, activating caspase-3 and triggering apoptosis.
