Table 1.
Adverse events with thiopurine therapy.
| Infection | Viral: |
| HSV varicella | |
| HPV varicella | |
| Tuberculosis | |
| PCP | |
| Liver toxicity | Nodular regeneration |
| Cholestasis | |
| Drug-induced hepatitis | |
| Viral hepatitis | |
| Lymphoma | Non-Hodgkin's |
| Usually EBV-related | |
| Background risk in IBD | |
| Other malignancy | Cervical dyskaryosis |
| Other malignancy uncommon | |
| Bone marrow suppression | 7% experience some; severe effect in 1.1% |
| Fertility and pregnancy | Consider risk vs benefit |
| Safe for pregnant women | |
| Teratogenicity rare in males | |
| Breastfeeding probably safe | |
| No effect on fertility |
EBV, Epstein-Barr virus; HPV, human papilloma virus; HSV, herpes simplex virus; IBD, inflammatory bowel disease; PCP, pneumocystis carinii pneumonia.