Table 1.

Level of support for the clinical, biologic, and genetic predictors of lithium response in bipolar disorder.

Variables	Level of support
Clinical variables
Course of illness	+++
Family history of BP	++
Family history of Li response	++
Age of BP onset	+++
Number of BP hospitalizations	+++
Classic BP symptomatology	+
Biologic variables
Normal EEG	+
ERPs	+
Brain imaging	+
Genetic variables
Single-gene association studies	+
Genome-wide association study	++

BP, bipolar disorder; EEG, electroencephalography; ERP, event-related potential; Li, lithium; +, weak evidence; ++, moderate evidence; +++, strong evidence.