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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Biomaterials. 2012 Nov 6;34(4):1311–1326. doi: 10.1016/j.biomaterials.2012.10.038

Table 1.

Research Design

Groups (G) Function groups Injections of Cell–Microsphere Beads in
Collagen I gel		 Doses of growth factors/injection Number of Grafts/
Number of Animals
G1 Control 1 Cell-free/empty beads 0 8/2
G2 Control 2 Human Myoblasts/empty beads 0 8/2
G3 Control 3 USCs/empty beads 0 8/2
G4 Control 4 USCs-EC/empty beads 0 8/2
G5 Control 5 Cell-free combine with IGF/NGF/FGF-1+VEGF+PDGF/HGF beads IGF (43.75ng), NGF(7.8 ng), FGF-1(15.625ng), VEGF (21.875 ng), PDGF-BB (12.5ng), HGF (62.5ng) 8/2
G6 Myogenic USCs combine with PDGF-BB/HGF beads PDGF-BB (37.5ng), HGF (187.5ng) 8/2
G7 Angiogenic USCs combine with VEGF beads VEGF (65.6 ng) 8/2
G8 Neurogenic USCs combine with IGF/NGF/FGF-1 beads IGF (131.25ng), NGF(23.44 ng), FGF-1(46.875ng) 8/2
G9 Synergetic 1 USCs combine with IGF/NGF/FGF-1 + VEGF + PDGF/HGF beads IGF (43.75ng), NGF(7.8 ng), FGF-1(15.625ng), VEGF (21.875 ng), PDGF-BB (12.5ng), HGF (62.5ng) 16/4
G10 Synergetic 2 USCs-ECs combine with IGF/NGF/FGF-1 + VEGF+ PDGF/HGF beads IGF (43.75ng), NGF(7.8 ng), FGF-1(15.625ng), VEGF (21.875 ng), PDGF-BB (12.5ng), HGF (62.5ng) 16/4