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. Author manuscript; available in PMC: 2012 Dec 4.
Published in final edited form as: J Immunol. 2009 Mar 15;182(6):3414–3422. doi: 10.4049/jimmunol.0801430

FIGURE 7.

FIGURE 7

Down-regulation of apopotic genes in lpr LN cell-infused recipient BM. C.B10 recipients pre-irradiated with 5 Gy TBI were infused with 5 × 106 LN cells from either lpr or B6 donors. Three weeks following cell infusion, recipients were euthanized and CD3−CD4−CD8−CD45R− BM cells were sorted for gene expression analysis using a PCR-based SuperArray system (A). Of the 360 total genes analyzed in the four categories, 75 genes showed more than two-fold down-regulation in lpr LN cell-infused recipient BM when compared to B6 (B). There was significant down-regulation in the expression of genes important in the regulation of cell apoptosis, such as Fas and caspase genes (C) as well as toll-like receptor genes (D). Data shown are from three recipients analyzed in each group.