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Model for cx-11 function in anterior neural plate induction in C. intestinalis. The a-lineage is induced by FGF9/16/20 from the neighboring A-lineage. At the neurula stage, cx-11 is expressed throughout the A- and a-lineages, and thus may contribute to signal propagation (most likely Ca2+ transients) between the A- and a-lineages (green arrow 2) or within the a-lineage (green arrow 1). a-line, a-lineage.
