Table 3.

Methylene blue synergized isopentaquine efficacy against relapse by Chesson strain P. vivax in American prisoner volunteers.

Methylene blue*	Isopentaquine‡	Quinine§	Relapsed/Challenged (%)	Followup Duration
0	60	0	9/10 (90%)	< 195 d
0	60	2,000	4/10 (40%)	167 – 374 d
500	60	0	3/9 (33%)	123 – 289 d
500	60	2,000	0/3 (0%)	249 d

Adapted from unpublished data of Alving et al. [29]

^*Milligrams of base & chloride salt of methylene blue, daily dose for 14 days.

^‡Milligrams of base daily for 14 days

^§Millgrams of the sulfate salt of quinine