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. 2012 Aug 20;198(4):677–693. doi: 10.1083/jcb.201202094

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© 2012 Elbediwy et al.

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Figure 8. — Cdc42 is a functionally important target of SH3BP1. Caco-2 cells were transfected with control, SH3BP1-, and Cdc42-specific siRNAs. For Cdc42, two different suboptimal concentrations, 20 and 30 nM, were used. (A and B) Depletion of SH3BP1 and Cdc42 was then analyzed by immunoblotting (A), and the effect on cell morphology and junction assembly was analyzed by immunofluorescence (B). (C) The effect on the ZO-1 distribution was then quantified as in Fig. 1 C. Shown are means ± 1 SD from three independent experiments (n = 3). The indicated p-values for double knockdown data are for comparisons with single SH3BP1 and Cdc42 depletions.