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. 2012 Aug 20;198(4):501–508. doi: 10.1083/jcb.201205058

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© 2012 Veltman et al.

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Figure 5. — Model of protrusion formation by SCAR and WASP in wild-type cells. Rac1 activation of the SCAR complex leads to new actin filament formation. We predict the following: (a) Feedback through actin filaments results in excitable behavior and a normal pseudopod cycle. (b) The Rac signal is turned off through negative feedback as the pseudopod matures. (c) In the absence of SCAR, protrusion formation is diminished, and active Rac levels increase until they engage WASP, which then replaces SCAR in essentially all respects. (d) In SCAR-null cells, as in wild-type cells, evolving pseudopods are formed through feedback, and normal protrusions are formed, though at a reduced frequency.