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. 2012 Aug 20;198(4):481–489. doi: 10.1083/jcb.201206050

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© 2012 Stehbens and Wittmann

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Microtubule-mediated vesicle trafficking pathways involved in FA dynamics. (A) ILK participates in microtubule stabilization near the leading cell edge, and is required for caveolin transport toward FAs. Caveolae may provide an alternative integrin endocytosis pathway. (B) Exocytosis of MT1-MMP is involved in ECM degradation around FAs. Transport of MT1-MMP vesicles requires microtubules, and ECM proteolysis may initiate FA disassembly. (C) Integrins are internalized by different endocytosis pathways and at least partially recycled back to the cell front. Clathrin-mediated endocytosis is thought to be involved in uptake of FA-associated, activated integrin molecules, whereas clathrin-independent pathways may be more important for endocytosis of inactive integrins. Arrows with broken lines indicate integrin transport and recycling pathways.