Table 2.
Current available, approved dopamine agonists
| compound | dose range | administration | half life |
|---|---|---|---|
| bromocriptine |
10 - 50 |
oral, t.i.d. |
3 – 6 |
| lisurid |
0.2 - 3 |
oral, 12 i.d. |
2 |
| pergolid |
0.5 - 6 |
oral, t.i.d. |
6-8 |
| dihydro-α-ergocryptine |
20 - 120 |
oral, t.i.d. |
16 |
| cabergoline |
0.5 - 4 |
oral, o.i.d. |
63 |
| rotigotine |
2 - 16 |
patch, t.i.d. |
24 |
| Pramipexol [retarded release] |
0.25 - 4.5 |
oral, t.i.d.[o.i.d. – b.i.d.] |
8 [24] |
| Ropinirol [retarded release] |
4 - 24 |
oral, o.i.d. [o.i.d. – b.i.d.] |
6 [24] |
| Piribedil retarded release | 50 - 250 | oral, t.i.d. | 21 |
Dose range is given in mg, only approved dopamine agonist with oral or transdermal administration are listed, plasma half life is given in hours, 10 mg bromocriptine correspond to approximately 400 mg LD/DDI.