Table 1.
Characteristics of 56 patients with non-small cell lung cancer and the relationship between E2F1 protein expression and clinicopathological variables
|
Variables |
Total (n = 56) |
E2F1 protein expression |
||
|---|---|---|---|---|
| Low (n = 35) | High (n = 21) | P value | ||
| Age at operation, years |
65.9 ± 11.1 |
66.8 ± 10.0 |
64.6 ± 12.8 |
NS |
| Gender |
|
|
|
|
| Male |
41 (73.2) |
27 (77.1) |
14 (66.7) |
NS |
| Female |
15 (26.8) |
8 (22.9) |
7 (33.3) |
|
| Smoking index, pack-years |
25.1 ± 32.0 |
29.6 ± 36.1 |
17.9 ± 23.1 |
NS |
| Tumor size, cm |
4.0 ± 1.6 |
4.0 ± 1.7 |
3.8 ± 1.5 |
NS |
| Histological type |
|
|
|
|
| Squamous cell carcinoma |
20 (35.7) |
14 (40.0) |
6 (28.6) |
NS |
| Adenocarcinoma |
33 (58.9) |
20 (57.1) |
13 (61.9) |
|
| Others |
3 (5.4) |
1 (2.9) |
2 (9.5) |
|
| T descriptor |
|
|
|
|
| T1 |
7 (12.5) |
3 (8.6) |
4 (19.0) |
NS |
| T2 |
38 (67.9) |
25 (71.4) |
13 (61.9) |
|
| T3 |
4 (7.1) |
1 (2.9) |
3 (14.3) |
|
| T4 |
7 (12.5) |
6 (17.1) |
1 (4.8) |
|
| N descriptor |
|
|
|
|
| N0 |
33 (58.9) |
20 (57.1) |
10 (61.9) |
NS |
| N1 |
10 (17.9) |
8 (22.9) |
4 (9.5) |
|
| N2 |
13 (23.2) |
7 (20.0) |
7 (28.6) |
|
| Stage |
|
|
|
|
| I |
26 (46.4) |
16 (45.7) |
10 (47.6) |
NS |
| II |
10 (17.9) |
6 (17.1) |
4 (19.0) |
|
| III |
20 (35.7) |
13 (37.2) |
7 (33.4) |
|
| Angiolymphatic invasion |
|
|
|
|
| Absent |
38 (67.9) |
23 (67.6) |
15 (75.0) |
NS |
| Present |
16 (28.5) |
11 (32.4) |
5 (25.0) |
|
| Unknown |
2 (3.6) |
|
|
|
| Histological grade |
|
|
|
|
| Well differentiated |
4 (7.1) |
3 (8.6) |
1 (5.3) |
NS |
| Moderately differentiated |
36 (64.3) |
23 (65.7) |
13 (68.4) |
|
| Poorly differentiated |
14 (25.0) |
9 (25.7) |
5 (26.3) |
|
| Unknown | 2 (3.6) | |||
NS not significant.
Continuous variables are expressed as mean ± SD; categorical variables are expressed as N (%).