Table 3.
KEGG Pathways enriched for genes upregulated in the inner cell mass or trophectoderm
| Term | Genes |
|---|---|
| Upregulated in Inner Cell Mass (A) | |
| Antigen processing and presentation |
CD74, CD8B, HSPA1L, HSPA6, PSME1, BoLA-DRB3 |
| Complement and coagulation cascades |
A2M, F2R, C1R, PLAUR, C4BPA, |
| Chemokine signaling pathway |
ITK, CCL24, CXCL7, GNAI1, GNB5, GNG7, PLCB1, STAT1, STAT4, STAT3 |
| Axon guidance |
EPHA4, CHP, DPYSL2, GNAI1, ROBO1, SEMA4G, SLIT2 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
CDH2, DES, GJA1, ITGA2, TCF7L2 |
| Pathways in cancer |
CDKN2B, FGF12, FGF16, ITGA2 MMP9, PDGFRA, STAT1, STAT4, STAT3, TCF7L2, FOS, KIT,WNT |
| Jak-STAT signaling pathway |
IL12RB2, IL19, IL6ST, IL7, STA1, STAT4, STAT3, SPRY2 |
| Hematopoietic cell lineage |
CD1A, CD8B, ITGA2, IL7, KIT |
| Upregulated in Trophectoderm (B) | |
| Lysosome |
ATP6V0A4, GM2A, NPC, CTSB, CTSH, CTSL2, CTNS, GLAA, GALC, MANBA, PLA2G15, SCARB2, ATP6V0C, SLC11A2 |
| Steroid biosynthesis |
NSDHL, CYP41A1, FDFT1, SC4MOL |
| Aldosterone-regulated sodium reabsorption |
ATP1B3, NEDD4L, PRKCG, SGK1, SFN |
| Vascular smooth muscle contraction |
ACTA2, ACTG2, CALD1, CALML5, ITPR2, MYLK, MYL6, PRKCH, PRKCG |
| PPAR signaling pathway |
ACSL4, AXSL6, FABP5, ACSL3, SCD, SCP2 |
| Phosphatidylinositol signaling system |
CALML3, ITPR2INPP4B, INPP5D, PRKCG, SYNJ1 |
| Pantothenate and CoA biosynthesis |
BCAT1, ENPP1, ENPP3 |
| Terpenoid backbone biosynthesis |
HMGCR, ACAT2, IDI1 |
| Sphingolipid metabolism |
UGCG, GLA, GALC, SGPP1 |
| Steroid hormone biosynthesis |
UGT1A1, UGT1A6, CYP11A1, CYP3A28, HSD3B1 |
| Fatty acid metabolism |
ACAT2, ACSL4, ACSL6, ACSL3 |
| ABC transporters | ABCA3,ABCB1, ABCC2, ABCG5 |