. 2012 Dec 4;7(12):e50970. doi: 10.1371/journal.pone.0050970

Table 1. Selected 45 tag SNPs for multilevel regression of continuous movement disorders.

Gene	Tag SNP	Chromosome Position	Alleles Public	ReferencesSNPs/Genes	TD^a		PK^a		AK^a		TDt^a		PF^a
			Major/Minor	Demonstratedassociations	Beta	p-value	Beta	p-value	Beta	p-value	Beta	p-value	Beta	p-value
GRIN2B		chr12∶13,714,410–14,133,022
	rs1805481	chr12∶13,763,205–13,763,705	AC		−0.03	0.6062	0.05	0.3529	−0.04	0.5621	−0.02	0.2882	0.08	0.4914
	rs7313149	chr12∶13,828,037–13,828,537	TC		0.02	0.7816	0.03	0.5460	−0.01	0.8739	0.00	0.9931	0.02	0.8586
	rs2192970	chr12∶13,836,063–13,836,563	CT		−0.12	0.1007	−0.07	0.2263	0.04	0.6385	0.00	0.7915	−0.14	0.2406
	rs2300242	chr12∶13,840,047–13,840,547	TA		0.01	0.9097	0.05	0.3792	0.01	0.9256	−0.01	0.4171	0.12	0.2904
	rs10845838	chr12∶13,894,146–13,894,646	GA		0.06	0.4429	−0.01	0.8834	−0.11	0.1218	−0.02	0.1964	0.08	0.4910
	rs12300851	chr12∶13,968,155–13,968,655	TC		–	–	–	–	–	–	–	–	–	–
	rs220599	chr12∶13,975,048–13,975,548	GA		−0.02	0.7367	0.04	0.4773	−0.01	0.8670	−0.01	0.4562	0.07	0.5170
	rs10772715	chr12∶14,037,753–14,038,253	GA		−0.10	0.1086	−0.07	0.1479	−0.02	0.7624	−0.01	0.3444	−0.20	0.0362
	rs12827536	chr12∶14,095,907–14,096,407	CT		−0.04	0.4927	0.02	0.6875	−0.02	0.7378	−0.01	0.4348	−0.04	0.7222
GRIN2A		chr16∶9,847,265–10,276,263
	rs11866328	chr16∶9,862,306–9,862,806	GT		0.12	0.0512	−0.02	0.7185	0.04	0.4868	0.02	0.2581	−0.02	0.8312
	rs11646587	chr16∶9,873,069–9,873,569	GA		−0.03	0.6401	−0.06	0.3363	0.02	0.7751	−0.02	0.2945	−0.11	0.3275
	rs7196095	chr16∶9,885,582–9,886,082	TC		0.02	0.7279	−0.02	0.7082	0.09	0.1678	−0.01	0.6353	−0.03	0.8048
	rs8049651	chr16∶9,943,416–9,943,916	CT		0.05	0.4769	0.02	0.7706	0.01	0.9313	−0.00	0.8313	0.08	0.4938
	rs9989388	chr16∶9,965,889–9,966,389	CT		−0.03	0.6765	0.08	0.2289	0.02	0.7748	−0.00	0.7958	0.14	0.2764
	rs9921541	chr16∶9,991,512–9,992,012	GT		−0.04	0.6482	0.03	0.6181	0.01	0.8932	−0.01	0.4727	0.07	0.5684
	rs4782039	chr16∶10,006,717–10,007,217	TC		−0.01	0.8343	0.01	0.9205	0.04	0.6066	0.00	0.8070	0.10	0.3853
	rs7190619	chr16∶10,078,874–10,079,374	GA		−0.01	0.9154	0.01	0.9256	−0.10	0.2778	0.02	0.3586	−0.08	0.5903
	rs9788936	chr16∶10,105,210–10,105,710	TC		0.05	0.5014	−0.03	0.6344	0.04	0.6484	0.01	0.7426	0.01	0.9558
	rs8057394	chr16∶10,115,238–10,115,738	GC		0.14	0.0525	0.04	0.4506	0.00	0.9916	0.01	0.3378	0.07	0.5246
	rs11644461	chr16∶10,120,640–10,121,140	TC		−0.13	0.0385	−0.02	0.6424	0.08	0.2276	−0.02	0.2136	−0.11	0.2730
	rs7192557	chr16∶10,123,219–10,123,719	GA		0.22	0.0159	0.08	0.2742	0.11	0.2443	0.00	0.9604	0.20	0.1877
	rs7206256	chr16∶10,196,673–10,197,173	AG		0.02	0.7845	0.02	0.7595	−0.00	0.9896	0.02	0.0919	0.00	0.9922
	rs1345423	chr16∶10,247,814–10,248,314	TG		−0.13	0.0421	0.01	0.8026	0.06	0.3536	−0.02	0.1442	−0.04	0.6942
	rs1650420	chr16∶10,268,080–10,268,580	GA		0.16	0.0193	−0.04	0.4499	−0.07	0.2912	0.02	0.1066	0.05	0.6514
HSPG2		chr1∶22,148,737–22,263,750
	rs2270697	chr1∶22,167,738–22,168,238	GT		0.01	0.9194	−0.05	0.4670	−0.01	0.8797	0.01	0.5993	−0.14	0.2999
	rs2445142	chr1∶22,225,493–22,225,993	GC	[28]–[30]	−0.05	0.4292	0.08	0.1685	0.06	0.4036	0.01	0.6816	0.19	0.0998
	rs6698486	chr1∶22,243,773–22,244,273	CT		−0.10	0.2250	0.12	0.0760	−0.02	0.8130	−0.00	0.8494	0.25	0.0625
DRD3		chr3∶113,847,557–113,897,899		[25], [31]–[38]
	rs9817063	chr3∶113,846,858–113,847,358	TC		−0.02	0.8083	−0.04	0.4632	−0.04	0.5922	0.02	0.2359	−0.01	0.9440
	rs2134655	chr3∶113,857,951–113,858,451	GA		0.02	0.7265	−0.05	0.4003	0.11	0.1409	0.03	0.0664	0.02	0.8868
	rs963468	chr3∶113,862,637–113,863,137	GA		−0.04	0.5906	0.03	0.5874	0.08	0.2021	−0.01	0.5302	−0.03	0.8098
	rs324035	chr3∶113,868,604–113,869,104	CA		0.00	0.9949	0.01	0.9005	−0.20	0.0392	−0.00	0.9592	0.12	0.4326
	rs3773678	chr3∶113,869,828–113,870,328	CT		−0.06	0.5968	0.05	0.5761	−0.21	0.0805	0.03	0.2130	0.18	0.3661
	rs167771	chr3∶113,876,025–113,876,525	AG		−0.06	0.5606	0.06	0.4746	−0.19	0.0512	0.00	0.9197	0.19	0.2265
	rs11721264	chr3∶113,879,154–113,879,654	GA		0.05	0.4688	−0.01	0.8877	−0.08	0.1930	−0.01	0.5338	−0.08	0.4382
	rs167770	chr3∶113,879,312–113,879,812	AG	[39]	0.05	0.3807	0.00	0.9367	−0.07	0.2411	−0.01	0.4278	−0.07	0.4798
	rs7633291	chr3∶113,886,818–113,887,318	TG	[39]	0.05	0.4719	0.00	0.9958	−0.05	0.5264	−0.02	0.1561	−0.08	0.4902
	rs1800828	chr3∶113,891,299–113,891,799	GC		0.01	0.8492	0.02	0.7948	−0.09	0.2275	−0.02	0.1701	0.02	0.8882
DRD4		chr11∶637,305–640,705		[40], [41]
	rs3758653	chr11∶636,149–636,649	TC	[42]	−0.02	0.7043	−0.02	0.6344	−0.01	0.8712	0.00	0.6300	−0.08	0.2617
HTR2C		chrX:113,818,551–114,144,624		[25], [33], [35], [43]–[46]
	rs569959	chrX:113,820,110–113,820,610	AG		0.01	0.8501	0.06	0.1606	−0.01	0.8138	−0.00	0.7311	0.11	0.1994
	rs17326429	chrX:113,826,117–113,826,617	GA		−0.07	0.3678	0.06	0.3194	−0.03	0.6436	−0.00	0.7743	0.14	0.2247
	rs12858300	chrX:113,897,163–113,897,663	GC		−0.03	0.6927	−0.10	0.1548	0.03	0.7543	−0.01	0.6958	−0.15	0.2892
	rs4911871	chrX:113,996,890–113,997,390	AG		−0.12	0.0634	0.02	0.7622	−0.06	0.3938	−0.01	0.6267	0.12	0.2648
	rs5946189	chrX:114,071,970–114,072,470	TC		0.03	0.5470	0.04	0.4574	−0.01	0.9251	0.02	0.0565	0.06	0.5314
	rs1801412	chrX:114,142,454–114,142,954	TG		−0.14	0.3456	−0.15	0.2627	−0.00	0.9991	−0.00	0.9149	−0.34	0.1571
NQO1		chr16∶69,743,304–69,760,533
	rs1800566	chr16∶69,744,895–69,745,395	CT	[47]	−0.14	0.1126	0.01	0.8486	0.02	0.7939	0.02	0.3708	−0.11	0.4720

Sources: UCSC (GRCh37/hg19), NCBI, SNPedia, Genecards, CHIP Bioinformatics Tools.

TD = tardive dyskinesia, PK = parkinsonism, AK = akathisia, TDt = tardive dystonia and PF = principal-factor.