Table 3.

Specificities obtained using Physiological Ligands

SH2 Domain	Specificity
ABL1	[pY] [D/E/S] [D/E] [P/N/D/E]
ABL2	[pY] [V] [N/Q]
BLK	[pY] [D/E/ϕ] [D/E/L] [P/I]
BRK	[pY] [D/E] [X] [D/E/ϕ]
CRK	[D] [X] [pY] [D] [V/L] [P] [P]
CRKL	[D] [X] [pY] [D] [ϕ] [P] [P/R]
DAPP1	[pY] [X] [X] [D/E/ϕ] [E]
FER	[D/E] [D/E] [pY] [D/G] [D/E] [ϕ]
FGR	[E] [P/D/E] [X] [pY] [D/E/G] [X] [D/E/ϕ] [Y]
FYN	[pY] [X] [D/ϕ] [ϕ]
GADS	[pY] [V] [N]
GRAP	[pY] [V/E] [N]
GRB2	[pY] [V/E] [N]
GRB7	[pY] [E] [N/Y]
HCK	[D/E] [D/P] [X] [pY] [D/E/G] [D/E/ϕ] [P/I/L]
ITK	[pY] [ϕ] [X] [D/ϕ]
LCK	[pY] [D/E/G] [D/E] [P/L] [P]
LYN	[pY] [D/E/G] [D/E] [P] [P]
MIST	[pY] [ϕ] [ζ] [ϕ] [D/E] [ϕ]
NCK1	[pY] [D/E] [E/L] [P/V]
PI3K1_N	[pY] [V/D] [X] [I/M/V]
PI3K1_C	[pY] [V/M/E] [N/T/M] [M]
PLCG1_C	[pY] [ϕ] [X] [D/E]
PTPN11_N	[pY] [ϕ] [X] [ϕ] [D/E] [ϕ]
RASA1_N	[pY] [ϕ] [X] [D/ϕ]
RASA1_C	[pY] [X] [X] [D/E/ϕ]
SH2B	[pY] [X] [X] [D/E/ϕ]
SH2D1B	[pY] [X] [X] [ϕ]
SH2D2A	[pY] [E] [N/T] [D/ϕ]
SH3BP2	[pY] [D/E] [N] [V]
SHB	[pY] [ϕ] [X] [ϕ] [D/E] [ϕ]
SHD	[pY] [ϕ] [X] [ϕ] [D/E] [ϕ]
SHE	[pY] [ϕ] [X] [ϕ] [D/E] [ϕ]
SHF	[pY] [ϕ] [X] [ϕ] [D/E] [ϕ]
SHC1	[pY] [D/E/G] [D/E/ϕ] [ϕ]
SLNK	[pY] [G/D/V] [D/T] [D/ϕ]
SRC	[D/E] [X] [X] [pY] [D] [D/E/ϕ] [P/I]
SYK_C	[ϕ] [pY] [V] [X] [D/E/ϕ] [D/E]
TENC1	[pY] [E]
VAV1	[pY] [V/E/L] [X] [P]
YES	[pY] [D/E/G] [D/E/ϕ] [ϕ]
ZAP70_N	[P] [X] [pY] [X] [X] [ψ/ϕ]

The general specificity information is obtained from the arrays is expressed in a regular expression form. Amino acid residues are indicated by their single-letter codes. Groups of amino acids are noted as φ = hydrophobic residues (Val, Ile, Leu, Phe, Trp, Tyr, Met); ψ = aliphatic residues (Val, Ile, Leu, Met); ζ = polar residues (Asn, Gln, Ser, Thr, Glu, Asp, Lys, Arg, His).