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AICAR prevents high-fat diet-induced ceramide accumulation in muscle. Male Wistar rats were fed a high-fat diet (HFD) and received daily injections of vehicle (saline) or AICAR (AIC; 0.5 mg/g body weight) for 6 wk. HFD alone did not significantly increase ceramides compared with the Chow-fed group, but HFD+AIC resulted in a significant reduction in ceramides compared with HFD alone. +p<0.05 for HFD+AICAR vs HFD (n=9-11).
