Table 2. Distribution frequency of CA9 genotypes in 519 healthy controls and 462 oral-cancer patients.
| Variable | Controls (N = 519) n (%) | Patients (N = 462) n (%) | OR (95% CI) | AOR (95% CI) |
| rs2071676 | ||||
| AA | 144 (27.7%) | 116 (25.1%) | 1.00 | 1.00 |
| AG | 262 (50.5%) | 238 (51.5%) | 1.128 (0.835–1.524) | 1.240 (0.806–1.908) |
| GG | 113 (21.8%) | 108 (23.4%) | 1.186 (0.828–1.700) | 1.056 (0.634–1.759) |
| AG+GG | 375 (72.3%) | 346 (74.9%) | 1.145 (0.861–1.523) | 1.179 (0.785–1.772) |
| rs3829078 | ||||
| AA | 484 (93.3%) | 417 (90.3%) | 1.00 | 1.00 |
| AG | 35 (6.7%) | 45 (9.7%) | 1.492 (0.941–2.366) | 0.901 (0.470–1.726) |
| GG | 0 (0%) | 0 (0%) | – | – |
| AG+GG | 35 (6.7%) | 45 (9.7%) | 1.492 (0.941–2.366) | 0.901 (0.470–1.726) |
| rs1048638 | ||||
| CC | 455 (87.7%) | 404 (87.4%) | 1.00 | 1.00 |
| CA | 61 (11.8%) | 54 (11.7%) | 0.997 (0.675–1.472) | 1.197 (0.682–2.102) |
| AA | 3 (0.5%) | 4 (0.9%) | 1.502 (0.334–6.750) | 2.755 (0.389–19.513) |
| CA+AA | 64 (12.3%) | 58 (12.6%) | 1.021 (0.698–1.492) | 1.267 (0.734–2.187) |
| 376del393 | ||||
| INS/INS | 394 (75.9%) | 370 (74.2%) | 1.00 | 1.00 |
| INS/Del | 120 (23.1%) | 114 (23.2%) | 1.024 (0.760–1.380) | 1.081 (0.710–1.645) |
| Del/Del | 5 (1.0%) | 5 (2.6%) | 2.757 (0.962–7.904) | 2.080 (0.551–7.853) |
| INS/Del+ Del/Del | 125 (24.1%) | 119 (25.8%) | 1.094 (0.818–1.461) | 1.135 (0.756–1.706) |
The odds ratios (ORs) and with their 95% confidence intervals (CIs) were estimated by logistic regression models. The adjusted ORs (AORs) with their 95% CIs were estimated by multiple logistic regression models after controlling for age, gender, betel-nut chewing, and tobacco and alcohol consumption.