Table 6. Distribution frequency of the clinical status and CA9 rs2071676 genotype frequencies in 462 patients with oral cancer.
| Genotypic frequencies | ||||
| Variable | AA (N = 116)n (%) | AG+ GG (N = 346) n (%) | OR (95% CI) | AOR (95% CI) |
| Clinical Stage | ||||
| Stage I/II | 59 (50.9%) | 154 (44.5%) | 1.00 | 1.00 |
| Stage III/IV | 57 (49.1%) | 192 (55.5%) | 1.290 (0.847–1.967) | 1.240 (0.774–1.987) |
| Tumor size | ||||
| ≤ T2 | 75 (64.7%) | 218 (63.0%) | 1.00 | 1.00 |
| > T2 | 41 (35.3%) | 128 (37.0%) | 1.074 (0.693–1.666) | 0.986 (0.601–1.615) |
| Lymph node metastasis | ||||
| No | 85 (73.3%) | 213 (61.6%) | 1.00 | 1.00 |
| Yes | 31 (26.7%) | 133 (38.4%) | 1.712 (1.076–2.725)* | 1.686 (1.002–2.839)* |
| Distant metastasis | ||||
| No | 116 (100%) | 338 (97.7%) | 1.00 | 1.00 |
| Yes | 0 (0%) | 8 (2.3%) | – | – |
| Cell differentiation | ||||
| Well | 20 (17.2%) | 48 (13.9%) | 1.00 | 1.00 |
| Moderately or poorly | 96 (82.8%) | 298 (86.1%) | 1.293 (0.731–2.287) | 1.328 (0.707–2.496) |
The odds ratios (ORs) with 95% confidence intervals (CIs) were estimated by logistic regression models. The adjusted ORs (AORs) with 95% CIs were estimated by multiple logistic regression models after controlling for age, gender, betel-quid chewing, alcohol consumption, and tobacco use.
> T2: tumor size >2 cm in greatest dimension.
*
Statistically significant at p<0.05.