Table 2.
Clinical characteristics of the sample
|
Switching |
Combination |
Augmentation |
Total |
|
|---|---|---|---|---|
| (N = 133) | (N = 80) | (N = 60) | (N = 273) | |
| Number of previous depressive episodes, mean (95%CI) |
1.8 (1.5-2.1) |
2.0 (1.5-2.4) |
3.5 (2.5-4.4) |
2.2 (1.9-2.5) |
| Previous hospitalization, n (%) |
12 (9.0) |
10 (12.5) |
15 (25.0) |
37 (13.6) |
| Previous suicide attempt, n (%) |
20 (15.2) |
17 (21.3) |
16 (26.7) |
53 (19.5) |
| Family history of psychiatric disorders, n (%) |
56 (42.1) |
44 (55.0) |
30 (50.0) |
130 (47.6) |
| Duration of AD treatment (weeks), mean (95%CI)* |
12.7 (10.7-14.6) |
10.6 (9.1-12.1) |
12.2 (8.3-16) |
12.0 (10.6-13.3) |
| Presence of psychotic symptoms, n (%) |
3 (2.3) |
5 (6.3) |
11 (18.3) |
19 (7.0) |
| MADRS total score, mean (95%CI) |
31.5 (30.3-32.6) |
32.5 (30.9-34.1) |
32.8 (30.9-34.6) |
32.1 (31.2-32.9) |
| MADRS Item 10 (suicidality) score, mean (95%CI) |
2.0 (1.7-2.2) |
2.3 (2.0-2.6) |
2.5 (2.2-2.7) |
2.2 (2.0-2.3) |
| HARS total score, mean (95%CI) |
24.3 (23.1-25.6) |
24.0 (22.3-25.6) |
23.0 (21.5-24.5) |
24.0 (23.1-24.7) |
| CGI-S score, mean (95%CI) | 4.5 (4.3-4.6) | 4.7 (4.5-4.8) | 4.7 (4.5-4.9) | 4.6 (4.5-4.6) |
*Antidepressant treatment for the current MDD episode at enrolment.
MADRS, Montgomery-Asberg Depression Rating Scale; HARS, Hamilton Anxiety Rating Scale; CGI-S, Clinical Global Impression – Severity scale.