Table 1.
Drugs shown to inhibit cough reflex sensitivity to capsaicin
| 1st author | Ref. # | Year | Drug | Subject population |
|---|---|---|---|---|
| Wise P |
[5] |
2012 |
menthol |
healthy volunteers |
| Takemura M |
[6] |
2012 |
montelukast |
cough-variant asthma |
| Ekstrand Y |
[7] |
2011 |
inhaled steroids |
asthma |
| Ishiura Y |
[8] |
2010 |
etodolac |
sinobronchial syndrome |
| Ishiura Y |
[9] |
2009 |
etodolac |
asthma |
| Dicpinigaitis P |
[10] |
2009 |
guaifenesin |
viral URI |
| Davenport P |
[11] |
2009 |
nicotine |
healthy smokers |
| Dicpinigaitis P |
[12] |
2008 |
tiotropium |
viral URI |
| Ishiura Y |
[13] |
2008 |
suplatast |
atopic cough |
| Ferrari M |
[14] |
2007 |
omeprazole |
asthma + GERD |
| Usmani O |
[15] |
2005 |
theobromine |
healthy volunteers |
| Shioya T |
[16] |
2004 |
epinastine |
atopic cough |
| Dicpinigaitis P |
[17] |
2003 |
guaifenesin |
viral URI |
| Ishiura Y |
[18] |
2003 |
carbocysteine |
asthma |
| Ishiura Y |
[19] |
2003 |
seratrodast |
chronic bronchitis |
| Shioya T |
[20] |
2002 |
suplatast |
cough-variant asthma |
| Dicpinigaitis P |
[21] |
2002 |
zafirlukast |
cough-variant asthma |
| Ceyhan B |
[22] |
2002 |
oxolamine |
COPD |
| Dicpinigaitis P |
[23] |
2000 |
baclofen |
cervical SCI |
| Brightling C |
[24] |
2000 |
budesonide |
eosinophilic bronchitis |
| Dicpinigaitis P |
[25] |
1998 |
baclofen |
healthy volunteers |
| Shioya T |
[26] |
1998 |
azelastine |
asthma |
| Dicpinigaitis P |
[27] |
1997 |
baclofen |
healthy volunteers |
| Shioya T |
[28] |
1996 |
azelastine |
cough-variant asthma |
| Fujimura M |
[29] |
1995 |
indomethacin |
asthma, chronic bronchitis |
| Hargreaves M |
[30] |
1995 |
sodium cromoglycate |
ACE-inhibitor cough |
| Hansson L |
[31] |
1994 |
lignocaine |
healthy volunteers |
| Van Wyck M |
[32] |
1994 |
glycopyrrolate |
ACE-inhibitor cough |
| Cazzola M |
[33] |
1993 |
theophylline |
ACE-inhibitor cough |
| Foster G |
[34] |
1991 |
sulindac |
healthy volunteers |
| McEwan J |
[35] |
1990 |
sulindac |
ACE-inhibitor cough |
| Choudry N |
[36] |
1990 |
lignocaine |
healthy volunteers |
| Fuller R | [37] | 1988 | codeine,morphine | healthy volunteers |
Abbreviations: URI-acute upper respiratory tract infection; GERD-gastroesophageal reflux disease; SCI-spinal cord injury; ACE-angiotensin-converting enzyme.