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. 2012 Dec 4;7(12):e50229. doi: 10.1371/journal.pone.0050229

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© 2012 Chen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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FACS result suggested that the apoptosis percentage was significantly elevated after the treatment of shRNA targeting Slug ( = 29.23, s = 4.72) compared with the non-transfected HSFBs ( = 2.36, s = 0.34) and the control group ( = 4.40, s = 0.50), respectively (A and B). In addition, shRNA targeting Slug markedly enhanced the activity of apoptosis related signal molecule caspase-3 (C), further supporting that Slug suppressed the apoptosis of HSFB, which ultimately resulted in the HS formation.

Inline graphic — FACS result suggested that the apoptosis percentage was significantly elevated after the treatment of shRNA targeting Slug ( = 29.23, s = 4.72) compared with the non-transfected HSFBs ( = 2.36, s = 0.34) and the control group ( = 4.40, s = 0.50), respectively (A and B). In addition, shRNA targeting Slug markedly enhanced the activity of apoptosis related signal molecule caspase-3 (C), further supporting that Slug suppressed the apoptosis of HSFB, which ultimately resulted in the HS formation.