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. 2012 Dec 4;7(12):e50229. doi: 10.1371/journal.pone.0050229

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© 2012 Chen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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. The mRNA levels of COL1 (A) and COL3 (B) in normal skin fibroblasts ( = 0.24, s = 0.06; = 0.28, s = 0.05, respectively) were significantly lower, compared with other three groups. However, there is no significant difference in mRNA levels of COL1 (A) and COL3 (B) in HSFBs transfected with Slug shRNA ( = 0.82, s = 0.08; = 0.78, s = 0.12, respectively), compared with non-transfected HSFBs ( = 0.95, s = 0.17; = 0.85, s = 0.08, respectively) and HSFBs transfected with control shRNA ( = 0.80, s = 0.11; = 0.92, s = 0.14, respectively), suggesting Slug shRNA had no effect on the collagen proteins synthesis in HS formation. *: P<0.01 versus Slug shRNA; ^†: P<0.01 versus Control shRNA; ^‡: P<0.01 versus HSFBs.

Inline graphic — . The mRNA levels of COL1 (A) and COL3 (B) in normal skin fibroblasts ( = 0.24, s = 0.06; = 0.28, s = 0.05, respectively) were significantly lower, compared with other three groups. However, there is no significant difference in mRNA levels of COL1 (A) and COL3 (B) in HSFBs transfected with Slug shRNA ( = 0.82, s = 0.08; = 0.78, s = 0.12, respectively), compared with non-transfected HSFBs ( = 0.95, s = 0.17; = 0.85, s = 0.08, respectively) and HSFBs transfected with control shRNA ( = 0.80, s = 0.11; = 0.92, s = 0.14, respectively), suggesting Slug shRNA had no effect on the collagen proteins synthesis in HS formation. *: P<0.01 versus Slug shRNA; ^†: P<0.01 versus Control shRNA; ^‡: P<0.01 versus HSFBs.