Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1981 Mar;31(3):1203–1208. doi: 10.1128/iai.31.3.1203-1208.1981

Serum inhibition of merozoite dispersal from Plasmodium falciparum schizonts: indicator of immune status.

T J Green, M Morhardt, R G Brackett, R L Jacobs
PMCID: PMC351443  PMID: 7014459

Abstract

Specific immune serum was found to inhibit the dispersal of the merozoites from mature schizonts, thus interfering with their subsequent reinvasion of new host erythrocytes. This phenomenon is viewed as a protective mechanism against malaria which can be measured in vitro and reflects the immune status of the donor.

Full text

PDF
1206

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkinson J. P., Glew R. H., Neva F. A., Frank M. M. Serum complement and immunity in experimental simian malaria. II. Preferential activation of early components and failure of depletion of late components to inhibit protective immunity. J Infect Dis. 1975 Jan;131(1):26–33. doi: 10.1093/infdis/131.1.26. [DOI] [PubMed] [Google Scholar]
  2. Brooks C., Kreier J. P. Role of the surface coat in in vitro attachment and phagocytosis of Plasmodium berghei by peritoneal macrophages. Infect Immun. 1978 Jun;20(3):827–835. doi: 10.1128/iai.20.3.827-835.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Campbell G. H., Mrema J. E., O'Leary T. R., Jost R. C., Rieckmann K. H. In vitro inhibition of the growth of Plasmodium falciparum by Aotus serum. Bull World Health Organ. 1979;57 (Suppl 1):219–225. [PMC free article] [PubMed] [Google Scholar]
  4. Chow J. S., Kreier J. P. Plasmodium berghei: adherence and phagocytosis by rat macrophages in vitro. Exp Parasitol. 1972 Feb;31(1):13–18. doi: 10.1016/0014-4894(72)90042-2. [DOI] [PubMed] [Google Scholar]
  5. Cohen S., Butcher G. A. Properties of protective malarial antibody. Immunology. 1970 Aug;19(2):369–383. [PMC free article] [PubMed] [Google Scholar]
  6. Green T. J., Kreier J. P. Demonstration of the role of cytophilic antibody in resistance to malaria parasites (Plasmodium berghei) in rats. Infect Immun. 1978 Jan;19(1):138–145. doi: 10.1128/iai.19.1.138-145.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jensen J. B., Trager W. Plasmodium falciparum in culture: establishment of additional strains. Am J Trop Med Hyg. 1978 Jul;27(4):743–746. doi: 10.4269/ajtmh.1978.27.743. [DOI] [PubMed] [Google Scholar]
  8. Ma N. S., Jones T. C., Miller A. C., Morgan L. M., Adams E. A. Chromosome polymorphism and banding patterns in the owl monkey (Aotus). Lab Anim Sci. 1976 Dec;26(6 Pt 2):1022–1036. [PubMed] [Google Scholar]
  9. Miller L. H., Aikawa M., Dvorak J. A. Malaria (Plasmodium knowlesi) merozoites: immunity and the surface coat. J Immunol. 1975 Apr;114(4):1237–1242. [PubMed] [Google Scholar]
  10. Mitchell G. H., Butcher G. A., Voller A., Cohen S. The effect of human immune IgG on the in vitro development of Plasmodium falciparum. Parasitology. 1976 Apr;72(2):149–162. doi: 10.1017/s0031182000048459. [DOI] [PubMed] [Google Scholar]
  11. Phillips R. S., Trigg P. I., Scott-Finnigan T. J., Bartholomew R. K. Culture of Plasmodium falciparum in vitro: a subculture technique used for demonstrating antiplasmodial activity in serum from some Gambians, resident in an endemic malarious area. Parasitology. 1972 Dec;65(3):525–535. doi: 10.1017/s0031182000044139. [DOI] [PubMed] [Google Scholar]
  12. Reese R. T., Motyl M. R. Inhibition of the in vitro growth of Plasmodium falciparum. I. The effects of immune serum and purified immunoglobulin from owl monkeys. J Immunol. 1979 Oct;123(4):1894–1899. [PubMed] [Google Scholar]
  13. Trager W., Jensen J. B. Human malaria parasites in continuous culture. Science. 1976 Aug 20;193(4254):673–675. doi: 10.1126/science.781840. [DOI] [PubMed] [Google Scholar]
  14. Williams A. I., Rosen F. S., Hoff R. Role of complement components in the susceptibility to Plasmodium berghei infection among inbred strains of mice. Ann Trop Med Parasitol. 1975 Jun;69(2):179–185. doi: 10.1080/00034983.1975.11686999. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES