. Author manuscript; available in PMC: 2012 Dec 5.

Published in final edited form as: Cancer Res. 2011 Aug 25;71(20):6360–6370. doi: 10.1158/0008-5472.CAN-11-0362

Table 4.

GR target genes (n=90) common to 1) MCF10A-Myc ChIP-seq, 2) MCF10A-Myc gene expression profiling and 3) ER−/GR-high (versus GR-low) primary human tumor gene expression

GBR location relative to TSS		Target genes found among all three datasets
GBR location relative to TSS		Related Functions	Genes
From 0 to 10kb	Upregulated	Cell Survival/ Proliferation/Apoptosis	C5AR1, DUSP1, RPS6KA2, SGK1
		Transcription/Chromatin Remodeling	PDE4DIP, SFRS13A, SMARCA2, ZFAND5, SAP30
		EMT/Cell Shape	PTGDS, SNAI2, EZR
		Inflammation	F3, NFKB1A, SAA1
		Lipid/fatty acid metabolism	PLCB4
		Miscellaneous	GRAMD3, SLC46A3
	Down-regulated	None	None
From 10 to 100kb	Upregulated	Cell Survival/Proliferation	BIRC3, CYR61, DUSP1, GADD45A, GADD45B, IGF2, IRS2, LEPR, LYRM1, MAP4K3, MCL1, NBN, NEDD9, PDE4DIP, PIAS1, PLCB4, PTGDS, RGS2, RHOBTB3, RPS6KA2, RTN1, SESN1
		Transcription/Chromatin Remodeling	CEP350, GTF2H1, NBN, NNMT, SMARCA2, TSC22D3, ZFAND5,* ZFP36L2, ZNF395*
		EMT/Cell Shape	ACTR2, ADI1, CALD1, CDC42EP3, CYR61, DPT, GPM6B, HPS5, IQGAP1, NEBL, NEDD9, PALLD
		Inflammation, Macrophage Function	CPM, CXCR4, CPM, IL1R1, SAA2
		Ion Transport, Energy	ATP2B4, SLC26A2, STOM
		Lipid/Fatty Acid Metabolism	ACSL1, STXBP3, TFPI
		Miscellaneous	COPS8, GRAMD3, LASS6, NACC2, PDLIM5, PICALM, RTN1, TTC37
	Down-regulated	Transcription/Chromatin Remodeling	ARID1A
	Down-regulated	Apoptosis	LIF

Bolded genes demonstrate GR occupancy in both proximal and distal genomic regions.