Table 3.
Changes in plasma biomarker levels from pre-HAART to on-HAART by abacavir exposure and cohort among (A) all 508 patient pairs and (B)184 persons who were ART-naïve at HAART initiation.
| A. All pairs (N=508) | B. Individuals ART-Naïve at HAART Initiation (N=184) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change from Pre-HAART Visit | Change from Pre-HAART Visit | ||||||||
| Non-ABC HAART | ABC HAART | Adjusted Difference of Change | p-value1 | Non-ABC HAART | ABC HAART | Adjusted Difference of Change | p-value2 | ||
| hsCRP | |||||||||
| MACS | 19% | 33% | 4% | 0.81 | -1% | -6% | 6% | 0.88 | |
| WIHS | 21% | 16% | -2% | 0.79 | 41% | -3% | -38% | 0.14 | |
| Combined | 21% | 22% | -1% | 0.93 | 20% | -4% | -20% | 0.35 | |
| D-dimer | |||||||||
| MACS | -23% | -41% | -24% | 0.06 | -38% | -57% | -23% | 0.34 | |
| WIHS | -19% | -20% | 7% | 0.36 | -28% | -26% | -8% | 0.68 | |
| Combined | -20% | -28% | -7% | 0.29 | -33% | -40% | -7% | 0.67 | |
| IL-6 | |||||||||
| MACS | -29% | -27% | 7% | 0.72 | -32% | -63% | -15% | 0.69 | |
| WIHS | -2% | 2% | -3% | 0.72 | 8% | -17% | -38% | 0.07 | |
| Combined | -12% | -9% | -9% | 0.24 | -12% | -38% | -21% | 0.26 | |
From linear mixed models of log-transformed on-HAART to pre-HAART ratios with random effect terms for each pair adjusted for ABC HAART exposure, age, calendar year, time between baseline and index visits, smoking, BMI, HDL, CD4 cell count, HIV RNA, and cohort.
From linear mixed models of log-transformed on-HAART to pre-HAART ratios with random effect terms for each individual adjusted for ABC HAART exposure, age, calendar year, time between baseline and index visits, smoking, BMI, HDL, CD4 cell count, HIV RNA, and cohort for WIHS (124 observations for 105 individuals) and combined models (204 observations for 184 individuals). Models for MACS were adjusted for the same factors but did not include random effects terms (80 observations for 79 individuals).