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. Author manuscript; available in PMC: 2012 Dec 5.
Published in final edited form as: Cancer Res. 2009 Feb 10;69(4):1324–1333. doi: 10.1158/0008-5472.CAN-08-3030

Figure 1.

Figure 1

Growth of LLC in WT and Ang-2–deficient mice. LLC tumors grew significantly slower in Ang-2–deficient mice (A). Tumor growth dissociated during early tumor growth when the tumors had grown to 0.2 to 0.4 cm3. Thereafter, tumor growth rates were almost identical as evidenced by essentially parallel curves of log-transformed tumor growth data (B). Total tumor weight was reduced in tumors grown in Ang-2–deficient mice (C). Yet, the differences in tumor weight at the end of the experiment resulted mostly from the dissociating exponential growth curves as a consequence of a dissociation of tumor growth curves during early stages of tumor growth. Tumors grown in WT mice grew cuboidal with almost spherical three-dimensional characteristics. In contrast, tumors grown in Ang-2–deficient mice had a flattened appearance (D). *, P < 0.001, compared with WT mice.