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Inhibition of PKCδ activity by CPM
| PKCδ | Percent inhibition of stimulated activity by 300 mM CPM |
|||||
|---|---|---|---|---|---|---|
| DG |
PMA |
|||||
| mean | SE | n | mean | SE | n | |
| Wild-type | 39.4 | ± 7.2 | 3 | 27.5 | ± 3.4 | 7 |
| Tyr-236-Phe | 35.5 | ± 4.8 | 3 | 7.1∗ | ± 1.3 | 7 |
Each data point in each experiment was calculated as the average of three to five replicates. n is the number of independent experiments.
p = 0.0001 compared with wild-type PKCδ activated with PMA (two-tailed, unpaired t-test).
