Table 4.
Overlap results of manually and automatically labeled cortical regions.
| DK atlas | DKT atlas | Multi-atlas | |
|---|---|---|---|
| TEMPORAL LOBE | |||
| L entorhinal | 81.85 (10.18) | 86.24 (9.94) | 85.38 (6.51) |
| R entorhinal | 77.15 (13.68) | 81.98 (14.58) | 81.16 (10.71) |
| L parahippocampal | 93.76 (4.98) | 95.71 (5.23) | 91.21 (3.90) |
| R parahippocampal | 93.05 (6.38) | 95.28 (6.88) | 91.64 (4.91) |
| L fusiform | 83.55 (5.41) | 89.46 (4.64) | 87.89 (3.48) |
| R fusiform | 83.76 (5.71) | 88.85 (5.41) | 87.51 (5.60) |
| L superior temporal | 82.35 (3.85) | 95.00 (2.55) | 94.34 (2.47) |
| R superior temporal | 81.53 (3.63) | 93.71 (3.03) | 93.38 (2.78) |
| L middle temporal | 83.55 (4.33) | 91.43 (3.75) | 89.75 (3.43) |
| R middle temporal | 86.72 (4.64) | 92.40 (4.67) | 91.17 (3.82) |
| L inferior temporal | 81.11 (7.47) | 89.17 (5.23) | 87.05 (4.06) |
| R inferior temporal | 85.95 (6.02) | 90.09 (4.86) | 88.37 (4.42) |
| L transverse temporal | 94.48 (5.17) | 95.63 (5.76) | 92.50 (4.58) |
| R transverse temporal | 90.22 (8.85) | 91.05 (9.44) | 87.11 (7.63) |
| FRONTAL LOBE | |||
| L superior frontal | 83.08 (4.92) | 90.23 (4.64) | 89.82 (3.60) |
| R superior frontal | 83.12 (4.58) | 89.81 (6.10) | 89.49 (4.31) |
| L rostral middle frontal | 80.66 (4.96) | 88.76 (5.77) | 88.48 (4.19) |
| R rostral middle frontal | 81.26 (5.45) | 86.21 (7.56) | 87.64 (3.25) |
| L caudal middle frontal | 92.86 (5.30) | 95.11 (5.53) | 89.51 (6.17) |
| R caudal middle frontal | 92.67 (4.92) | 95.21 (5.41) | 89.50 (6.25) |
| L pars opercularis | 84.72 (7.18) | 87.17 (7.96) | 85.00 (9.08) |
| R pars opercularis | 81.06 (9.69) | 82.80 (10.02) | 83.96 (9.38) |
| L pars triangularis | 77.13 (7.55) | 84.81 (9.50) | 84.10 (9.26) |
| R pars triangularis | 75.33 (10.06) | 76.57 (12.85) | 76.72 (11.20) |
| L pars orbitalis | 51.37 (13.16) | 82.79 (15.48) | 81.26 (15.00) |
| R pars orbitalis | 54.68 (13.56) | 74.50 (13.32) | 70.25 (11.17) |
| L lateral orbitofrontal | 82.65 (3.38) | 93.12 (2.84) | 93.16 (2.28) |
| R lateral orbitofrontal | 83.63 (2.87) | 94.23 (2.85) | 93.53 (2.33) |
| L medial orbitofrontal | 80.75 (7.02) | 91.37 (5.93) | 90.09 (4.60) |
| R medial orbitofrontal | 76.40 (8.01) | 90.78 (5.35) | 89.31 (3.17) |
| L precentral | 94.62 (2.93) | 96.22 (3.06) | 92.99 (4.42) |
| R precentral | 93.40 (3.60) | 96.52 (3.80) | 93.63 (3.91) |
| L paracentral | 86.92 (5.43) | 92.67 (6.21) | 89.24 (7.06) |
| R paracentral | 90.10 (5.14) | 92.19 (5.62) | 89.67 (5.56) |
| PARIETAL LOBE | |||
| L postcentral | 89.63 (4.26) | 93.52 (4.25) | 89.73 (5.99) |
| R postcentral | 91.53 (2.80) | 96.07 (3.13) | 93.04 (2.85) |
| L supramarginal | 88.38 (5.03) | 89.84 (5.63) | 87.39 (4.69) |
| R supramarginal | 87.99 (4.02) | 89.59 (4.04) | 87.08 (5.04) |
| L superior parietal | 85.29 (3.58) | 92.64 (3.29) | 87.94 (4.68) |
| R superior parietal | 85.06 (4.60) | 91.31 (4.88) | 89.03 (4.67) |
| L inferior parietal | 87.81 (5.51) | 89.93 (5.91) | 87.41 (5.70) |
| R inferior parietal | 88.21 (4.60) | 89.83 (4.93) | 88.26 (4.03) |
| L precuneus | 93.05 (2.31) | 96.26 (2.79) | 93.04 (3.02) |
| R precuneus | 91.38 (2.88) | 95.00 (3.33) | 92.19 (2.61) |
| OCCIPITAL LOBE | |||
| L lingual | 96.93 (2.42) | 97.71 (2.46) | 95.12 (2.94) |
| R lingual | 97.01 (3.89) | 97.91 (4.04) | 95.15 (3.66) |
| L pericalcarine | 95.78 (5.11) | 97.40 (5.20) | 92.75 (4.80) |
| R pericalcarine | 95.44 (4.83) | 96.99 (4.88) | 91.75 (4.23) |
| L cuneus | 80.33 (5.19) | 93.64 (5.58) | 89.63 (5.41) |
| R cuneus | 80.35 (7.59) | 90.06 (7.38) | 85.24 (7.32) |
| L lateral occipital | 87.79 (4.07) | 90.40 (4.17) | 88.18 (3.35) |
| R lateral occipital | 85.94 (5.72) | 88.05 (5.97) | 87.27 (5.13) |
| CINGULATE CORTEX | |||
| L rostral ant. cingulate | 82.34 (8.42) | 88.23 (10.15) | 85.74 (7.92) |
| R rostral ant. cingulate | 81.12 (13.42) | 86.78 (13.40) | 82.95 (11.53) |
| L caudal ant. cingulate | 72.96 (16.62) | 87.80 (7.40) | 68.13 (7.06) |
| R caudal ant. cingulate | 83.52 (15.49) | 85.69 (14.86) | 63.50 (9.82) |
| L post. cingulate | 91.69 (6.25) | 95.57 (5.92) | 93.25 (4.55) |
| R post. cingulate | 92.19 (5.91) | 95.87 (5.02) | 93.74 (4.53) |
| L isthmus cingulate | 93.21 (3.84) | 94.93 (4.00) | 93.56 (3.80) |
| R isthmus cingulate | 90.82 (15.00) | 92.68 (15.24) | 90.11 (14.93) |
| L insula | 88.82 (1.50) | 98.51 (1.29) | 97.72 (0.93) |
| R insula | 89.57 (2.68) | 98.77 (1.29) | 97.77 (0.87) |
All numbers are Dice overlap measures between manual and automated labels, averaged (with SD) across 42 (NKI-RS-22 and NKI-TRT-20) subjects. Automated labels were generated using FreeSurfer’s DK classifier atlas, our DKT40 classifier atlas, and by multi-atlas registration. In no case was the atlas used to label a participant’s brain image constructed using that participant’s brain image. In multi-atlas registration, each of the labeled brains used to construct the DKT40 classifier atlas was registered to a subject via an average surface template, resulting in multiple labels for each vertex of the subject’s surface, and a single label was chosen by majority-vote rule. Overlap was computed after propagating the surface labels through the subject’s gray matter mask. Since the DK atlas column uses an atlas constructed from non-Mindboggle-101 image data and uses a different labeling protocol than the other two columns, the overlap measures are not intended to be compared with the other columns but may instead be considered benchmark overlap measures when using the standard FreeSurfer atlas. Likewise, the DKT40 atlas and multi-atlas columns may be used as benchmark overlap measures when using the DKT40 atlas or multiple Mindboggle-101 atlases. According to a Wilcoxon signed-rank test, the DKT40 atlas values are significantly greater than the multi-atlas values (p < 10−10).