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. 2012 Dec 5;6:82. doi: 10.3389/fncir.2012.00082

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Copyright © 2012 Tricoire and Vitalis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Embryonic origin of nNOS⁺ hippocampal interneurons. (A) Images illustrating the coexpression of GFP and nNOS in the Nkx2.1Cre:RCE (left) and GAD65-GFP (right) mouse lines. Scale bar: 25 μm. (B) Nkx2.1 is necessary for the specification of nNOS⁺ interneurons. Top, In situ hybridization against Lhx6 transcripts on hippocampus of control (left) and mutant (right) P15 mice after conditional loss of Nkx2.1 function at E10.5. Scale bar: 200 μm. Bottom, Immunohistochemical expression patterns of nNOS in CA1 of control and mutant mice. Scale bar: 50 μm. Adapted from Tricoire et al. (2010, 2011).