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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: J Neurochem. 2012 Nov 1;123(6):954–962. doi: 10.1111/jnc.12047

Figure 3. HIF- and S1P1-based regulation of CCL2 expression in response to preconditioning by hypoxia and FTY720.

Figure 3

(A) HPC increases CCL2 protein expression when measured 12 h after the cessation of HPC, but this increase is attenuated if both HIF isoforms are inhibited during HPC by R59949 or if the S1P1 receptor is antagonized during HPC by W146. (B) FTY720 increases CCL2 protein expression 6 h after FTY720 administration, but this increase is abrogated by inhibition of HIF prior to FTY720 administration with R59949, or antagonism of S1P1 prior to FTY720 administration with W146. Data represent mean±SEM. N=4–8 per group. (*) P<0.05 between groups.